The goal of this clinical trial is to explore whether preoperative stimulation of the distal limb of the ileostomy loop with gamma aminobutyric acid (GABA) could effectively reduce the incidence of complications after ileostomy closure.

Participants will be divided into two groups. One group included patients treated with stimulation of the efferent loop with GABA prior to transit reconstruction surgery; the other control group was stimulated without giving any substance.

Researchers will compare incidence of complications such as postoperative ileus, diarrhea and other parameters such as time to tolerating a diet, start of the passage of flatus, start of the passage of stool, postoperative stay, etc.

Inclusion Criteria:

• over 18 years of age;
• body mass index (BMI) 18.5-28 kg/m2;
• having protective ileostomy after colorectal carcinoma surgery free of disease;
• with endoscopic and histological confirmation of diversion colitis;
• no oral antibiotics within 3 months;
• having signed the informed consent.

Exclusion Criteria:

• under 18 years of age;
• clinical history, and histological confirmation of inflammatory bowel disease with colorectal involvement;
• history of neoadjuvant or adjuvant chemoradiotherapy;
• other serious chronic diseases, such as cardiovascular and cerebrovascular diseases, diabetes, respiratory diseases, etc;
• serious perioperative complications such as anastomotic rupture after surgery;
• oral antibiotics within three months;
• participation in any other studies within the past 3 months.