Levetiracetam Prophylaxis in Brain Tumor Resection Pilot

Pilot Study: Levetiracetam Prophylaxis Randomized Controlled Trial in Brain Tumor Resection

This study aims to evaluate feasibility of a double-blind randomized controlled trial for levetiracetam prophylaxis for prevention of seizure in the perioperative phase of brain tumor resection.

Inclusion Criteria:

• Adult age 18 years or older
• Undergoing craniotomy for a brain tumor
• Intra-axial tumor location
• Supratentorial tumor location

Exclusion Criteria:

• Documented seizure history or epilepsy diagnosis
• Currently taking an antiepileptic medication
• Unable to take levetiracetam (e.g. allergy, inability to swallow)
• Inability to obtain consent from participant or substitute decision maker prior to surgery
• Renal impairment with eGFR less than 50
• Pregnancy