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The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact on body composition, muscle strength, and blood parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ketogenic diet | Experimental | Participants will perform a single exercise bout after 4 weeks of resistance training combined with a ketogenic diet (KD group). |
|
| western diet | Active Comparator | Participants will perform a single exercise bout after 4 weeks of resistance training combined with a western diet (WD group). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| resistance training | Other | All participants perform a four-day resistance training aimed to stimulate a hypertrophic response. |
|
| Measure | Description | Time Frame |
|---|---|---|
| mammalian target of rapamycin (mTOR) signalling | Measurement of the change in muscle protein anabolic signalling pathway in response to a single bout of resistance exercise by western blot analysis. | Change from baseline to 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle mass | Measurement of the change in kilograms of muscle mass via Dexa | Change from baseline to 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Giuseppe Cerullo | Contact | +00393200218377 | giuseppe.cerullo@unipd.it |
| Name | Affiliation | Role |
|---|---|---|
| Antonio Paoli, MD | University of Padova | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nutex LAB | Recruiting | Padua | 35131 | Italy |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| D055423 | Diet, Ketogenic |
| D066273 | Diet, Western |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| ketogenic diet | Other | Subjects allocated to the ketogenic diet arm (KD group) consume less than 50 g of carbohydrates per day. |
|
| western diet | Other | Subjects allocated to the western diet arm (WD group) consume a standard diet based on 55% of their daily calories from carbohydrates. |
|
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D050528 | Diet, Carbohydrate-Restricted |
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |