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The goal of this observational study is to learn about risk of progressive pulmonary fibrosis (PPF). The main questions it aims to answer are:
Patients with interstitial lung disease (ILD) of known or unknown etiology other than IPF who has radiological evidence of pulmonary fibrosis will enroll in this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PF | Patients with interstitial lung disease (ILD) of known or unknown etiology other than IPF who has radiological evidence of pulmonary fibrosis(PF). |
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| Measure | Description | Time Frame |
|---|---|---|
| Establish the correlation between Age (years) and progression to PPF | Up to 12 months | |
| Establish the correlation between Gender (the proportion of female and the proportion of male) and progression to PPF | Up to 12 months | |
| Establish the correlation between Body mass index (BMI, kg/m2) and progression to PPF | Up to 12 months | |
| Establish the correlation between ILD-Gender-Age-Physiology score (0-3,4-5 and 6-8) and progression to PPF | Up to 12 months | |
| Establish the correlation between Artery blood gas and progression to PPF | Artery blood gas: PaCO2 (mmHg) and PaO2 (mmHg) | Up to 12 months |
| Establish the correlation between Pulmonary function and progression to PPF | Pulmonary function: forced vital capacity (FVC, L) and diffusion capacity for carbon monoxide of the lung (DLCO, mmol/min/kPa) | Up to 12 months |
| Establish the correlation between 6 min walk test distance (meters) and progression to PPF | Up to 12 months | |
| Establish the correlation between Biomarkers and progression to PPF | Biomarkers:CCL18(pg/mL),KL-6(pg/mL),CA125(pg/mL),MMP-7(pg/mL),SP-D(pg/mL) and IL-6(pg/mL) | Up to 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of PPF | Prevalence of PPF in patients with fibrosing ILD. | Up to 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Establish the correlation between Age (years) and mortality of PPF | Up to 36 months | |
| Establish the correlation between Gender (the proportion of female and the proportion of male) and mortality of PPF | Up to 36 months |
Inclusion Criteria:
Exclusion Criteria:
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Patients from the first affiliated Hospital of Shandong first Medical University,Jinan Central Hospital,Jinan people's Hospital,The fourth people's Hospital of Jinan and PLA 960 Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| zhi guo, Doctor | Contact | +8613853120761 | guozhi770217@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Shandong First Medical University | Recruiting | Jinan | Shandong | 250000 | China |
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| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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serum
| Establish the correlation between Body mass index (BMI, kg/m2) and mortality of PPF | Up to 36 months |
| Establish the correlation between ILD-Gender-Age-Physiology score (0-3,4-5 and 6-8) and mortality of PPF | Up to 36 months |
| Establish the correlation between Artery blood gas and mortality of PPF | Artery blood gas: PaCO2 (mmHg) and PaO2 (mmHg) | Up to 36 months |
| Establish the correlation between Pulmonary function and mortality of PPF | Pulmonary function: forced vital capacity (FVC, L) and diffusion capacity for carbon monoxide of the lung (DLCO, mmol/min/kPa) | Up to 36 months |
| Establish the correlation between 6 min walk test distance (meters) and mortality of PPF | Up to 36 months |
| Establish the correlation between Biomarkers and mortality of PPF | Biomarkers:CCL18(pg/mL),KL-6(pg/mL),CA125(pg/mL),MMP-7(pg/mL),SP-D(pg/mL) and IL-6(pg/mL) | Up to 36 months |