Per the PI, the project is not IRB approved yet and will likely not be completed.

The current literature suggests that zinc supplementation may increase the duration of botulinum toxin; however, each study had their limitations. Further, no one has studied the effect of zinc supplementation for botulinum toxin treatment of the forehead. The purpose of this study is to evaluate the effect of zinc supplementation on frontalis muscle denervation by objectively assessing the degree of forehead rhytids and movement of the eyebrows.

Inclusion Criteria:

Any patient older than 18 years old who desires botulinum toxin injection to decrease forehead rhytids

Exclusion Criteria:

• Allergy to any components of zinc citrate or botulinum toxin
• inflammation or infection at site of injection
• patients using anticholineresterase or other agents interfering with neuromuscular transmission
• patients with any medical condition that can affect frontalis function (Bell's palsy, Möbius syndrome, Hemifacial microsomia, CHARGE syndrome, stroke, etc)
• patients with any prior trauma that could have potentially injured the frontalis muscle
• patients dependent on intact facial movements and expressions for their livelihood (actors, singers, musicians, etc)