The purpose of this study is to investigate the efficacy and safety of the combination of venetoclax and HAA regimen in young, newly diagnosed acute myeloid leukemia patients under the age of 60.

Inclusion Criteria:

• The eligible subjects for enrollment in this study must meet all of the following criteria:

  1. Patients with acute myeloid leukemia (excluding APL) who meet the diagnostic criteria of the World Health Organization (WHO) 2016 classification.
  2. Patients with AML and multilineage dysplasia (MDS) and/or myeloproliferative neoplasms (MPN) who meet the WHO criteria without prior history of MDS or MPN.
  3. Patients with AML who are not classified separately according to the WHO classification, except for those with acute megakaryoblastic leukemia with bone marrow fibrosis or myeloid sarcoma.
  4. Age greater than 16 years and less than 60 years, regardless of gender.
  5. Eastern Cooperative Oncology Group performance status (ECOG-PS) of 0-2.
  6. Requirements for laboratory parameters (within 7 days prior to treatment initiation) include: aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) ≤3 times the upper limit of normal (ULN); serum bilirubin ≤2×ULN; serum cardiac enzyme <2.0×ULN; serum creatinine ≤2.0×ULN; and echocardiogram (ECHO)-determined ejection fraction within the normal range.
  7. A signed informed consent form is required before any study-specific procedures are performed. Patients 18 years and older may sign the informed consent form themselves or have it signed by their next of kin. Patients under 18 years of age must have the informed consent form signed by their legal guardian. In consideration of the patient's medical condition, if it is not in the patient's best interest to sign the form, the legal guardian or patient's next of kin may sign the form on the patient's behalf.

Exclusion Criteria:

• Subjects meeting any of the following criteria will be excluded from this study:

  1. Previously treated patients (including those who have undergone induction chemotherapy regardless of treatment response).
  2. Secondary leukemia (including therapy-related AML subtype according to the World Health Organization (WHO) classification and those with a history of MDS and/or MPD).
  3. Concomitant hematologic diseases (such as hemophilia or myelofibrosis) deemed unsuitable for inclusion by the investigator; individuals with prior abnormal blood counts are allowed to participate if they have been previously excluded from MDS and MPD.
  4. Other malignant tumors requiring treatment.
  5. Pregnant or lactating women. Female participants of childbearing potential must have a negative pregnancy test within 7 days prior to the start of the trial. Male or female participants must take contraceptive measures during the trial and for 3 years after completion of treatment.
  6. Significant abnormalities in liver or kidney function beyond the inclusion criteria.
  7. Active heart disease, defined as one or more of the following:
  1. History of uncontrolled or symptomatic angina pectoris;
  2. Myocardial infarction within 6 months prior to enrollment;
  3. History of arrhythmia requiring medication or with severe clinical symptoms;
  4. Uncontrolled or symptomatic congestive heart failure (> NYHA class 2);
  5. Ejection fraction below the lower limit of the normal range. 8. Severe infectious diseases (e.g., unhealed tuberculosis or pulmonary aspergillosis).

  9. Participants deemed unsuitable for inclusion by the investigator.