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Type 1 diabetes is associated with many longterm complications as retinopathy,neuropathy and nephropathy. Recently, several studies have linked type 1 diabetes to bone fragility.Studies conducted on patients with type 1 diabetes have concluded that bone is negatively affected in type 1 diabetes with impaired bone density,increased fracture risk and impaired bone turnover markers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cases group | childern and adolescents with type 1 diabetes |
| |
| control group | age and sex matched control childern and adolsecents |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| serum ostecalcin,serum sclerostin and parathroid profile | Diagnostic Test | evaluation of bone turnover markers in blood |
|
| Measure | Description | Time Frame |
|---|---|---|
| level of serum ostecalcin, sclerostin in patients with type 1 diabetes ann d their age and sex matched control | markers of bone turnover in patients with type 1 diabetes and their matched control | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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childern and adolsecents below 16 years of age diagnsed with type 1 diabetes for at least 1 year age and sex-matched control childern and adolsecents will be included
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hajar M Ismail, resident | Contact | 01068447853 | hagermoamen@med.sohag.edu.eg | |
| Ahmed M Monir, assistant professor | Contact |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag university Hospital | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31819579 | Background | Starup-Linde J, Hygum K, Harslof T, Langdahl B. Type 1 Diabetes and Bone Fragility: Links and Risks. Diabetes Metab Syndr Obes. 2019 Dec 3;12:2539-2547. doi: 10.2147/DMSO.S191091. eCollection 2019. | |
| 31840392 | Background | Madsen JOB, Herskin CW, Zerahn B, Jensen AK, Jorgensen NR, Olsen BS, Svensson J, Pociot F, Johannesen J. Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2020 Mar;21(2):366-376. doi: 10.1111/pedi.12963. Epub 2019 Dec 27. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Dec 11, 2024 | |
| Reset | Jan 24, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Dec 11, 2024 | Jan 24, 2025 |
| ID | Term |
|---|---|
| D003922 | Diabetes Mellitus, Type 1 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| 33038875 | Background | El Amrousy D, El-Afify D, Shabana A. Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus. Pediatr Res. 2021 Mar;89(4):878-881. doi: 10.1038/s41390-020-01197-5. Epub 2020 Oct 10. |
| 30286569 | Background | Roh JG, Yoon JS, Park KJ, Lim JS, Lee HS, Hwang JS. Evaluation of bone mineral status in prepuberal children with newly diagnosed type 1 diabetes. Ann Pediatr Endocrinol Metab. 2018 Sep;23(3):136-140. doi: 10.6065/apem.2018.23.3.136. Epub 2018 Sep 28. |
| D004700 | Endocrine System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |