We categorized the marital status of the study population into three major groups: married, unmarried, and divorced.

We categorized the educational level of the study population into three categories: primary school or below, junior high school or high school, and college or above.

We classified the patients' satisfaction with their current economic situation into three categories: comfortable, manageable, and challenging.

Smoking history: Never smoked, Former smoker, Current smoker.

DAS28 (Disease Activity Score 28) is a scale used to assess the activity level of rheumatoid arthritis (RA). It is calculated based on the assessment of joint swelling, joint tenderness, systemic inflammatory markers (erythrocyte sedimentation rate), and the patient's self-assessment of pain using a visual analog scale (VAS). The specific formula for calculating DAS28 (Disease Activity Score 28) is as follows:

DAS28 = 0.56 * √(TJC28) + 0.28 * √(SJC28) + 0.36 * ln(CRP) + 0.014 * GH + 0.96 The DAS28 calculation includes the examination of 28 joints, including the fingers and wrists, elbows, shoulders, knees, and ankles. The DAS28 score ranges from 0 to 10, with higher scores indicating higher disease activity. Common classification criteria include low disease activity (DAS28 < 3.2), moderate disease activity (3.2 ≤ DAS28 < 5.1), and high disease activity (DAS28 ≥ 5.1).

Light physical activity: Refers to activities such as prolonged standing or walking, office work, light household chores, etc.

Moderate physical activity: Refers to activities that involve more walking, standing work, moderate household chores, farming, and light physical work.

Heavy physical activity: Refers to activities such as prolonged walking or running, heavy physical work, sports athletes, and other high-intensity activities.

The Health Assessment Questionnaire Disability Index (HAQ-DI) is a commonly used scale for assessing the level of functional disability in patients' daily activities. It covers various activities such as getting up, dressing, bathing, eating, walking, and climbing stairs. Patients are required to rate each item based on their actual abilities to reflect their level of functional impairment. The scoring typically ranges from 0 to 3, with 0 indicating no functional disability and 3 indicating severe functional impairment.The minimum value is 0, and the maximum value is 60.

By calculating the total score of HAQ-DI, the quantified assessment of patients' daily life functioning can be obtained. This index can be used to evaluate treatment effectiveness, disease progression, and quality of life changes in patients.

Note that HAQ-DI is not only used for assessing patients with rheumatoid arthritis but can also be applied to functional assessment in other chronic diseases.

The Fatigue Self-Assessment Scale (FSAS) is developed based on a review of research on fatigue assessment both domestically and internationally, taking into account Chinese language habits and cultural characteristics. The scale consists of 23 items and is used to assess the types and severity of fatigue in sub-healthy individuals and various patient populations with fatigue-related symptoms. It includes three factors: physical fatigue, mental fatigue, and consequences of fatigue. It also evaluates three characteristics of fatigue: response to sleep/rest, situational factors, and temporal patterns. The scale can be used to assess the effectiveness of interventions targeting fatigue. The minimum score is 0, and the maximum score is 88, with higher scores indicating greater levels of fatigue.

The Pittsburgh Sleep Quality Index (PSQI) is a self-report questionnaire used to assess an individual's sleep quality and disturbances over a one-month time period. It consists of 19 items that cover several aspects of sleep, including sleep duration, sleep latency, sleep disturbances, use of sleep medications, and daytime dysfunction. The questionnaire is scored on a 0 to 3 scale for each item. The total score ranges from 0 to 21, with a higher score indicating worse sleep quality. The PSQI is commonly used in research and clinical settings to evaluate sleep problems and monitor treatment outcomes.

For example, hypertension, diabetes, Sjogren's syndrome, etc. We do not document diseases that have been treated with surgical procedures, such as uterine fibroids that have been removed.

Mainly record the medication used by patients to treat rheumatoid arthritis in the past half month. For example, methotrexate, leflunomide, hydroxychloroquine, etc

Alcohol history: Never drank, Former drinker, Current drinker.

Surgical history: No history of surgery, History of surgery.

Erythrocyte sedimentation rate (ESR) is a blood test that measures the rate at which red blood cells settle in a vertical tube over a specific period of time. It is a non-specific marker of inflammation and is commonly used as a screening test to assess the presence and severity of inflammatory conditions in the body.

White blood cell count, also known as leukocyte count, is a blood test that measures the number of white blood cells (leukocytes) present in a specified volume of blood. White blood cells are an essential part of the immune system.

When the test result is negative or 1:20, we consider it negative. When the result is 1:40, we consider it weakly positive. When the result is 1:60 or higher, we consider it positive.

Anti-cyclic citrullinated peptide antibody (anti-CCP antibody) is a type of autoantibody that targets the synthetic cyclic citrullinated peptide (CCP) antigen. It has high sensitivity and specificity for rheumatoid arthritis (RA), making it a highly specific marker for early diagnosis of RA. Furthermore, patients who test positive for this antibody are more likely to develop severe joint damage compared to those who test negative for the antibody.

Hypersensitivity C-reactive protein (hsCRP) is a highly sensitive blood biomarker for measuring C-reactive protein levels. It is measured in milligrams per liter (mg/L). The level of hsCRP in the blood reflects the level of inflammation in the body.

Rheumatoid factor (RF) is an autoantibody that targets the Fc portion of immunoglobulin G (IgG) antibodies. It is measured in international units per milliliter (IU/ml). Elevated levels of RF in the blood are commonly associated with rheumatoid arthritis (RA) and other autoimmune conditions. The presence of RF in the blood indicates an immune system response and can contribute to the diagnosis and management of RA.

VAS (Visual Analog Scale) is a pain assessment scale that uses a ruler divided into 10 equal parts. A score of 0 represents no pain, while a score of 10 represents the highest level of pain.