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This is pilot study to establish a rapid autopsy program in Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center and outline the components necessary for tumor tissue collection.
The goal of this project to establish a rapid autopsy program in SCLC at the IUSCCC and outline the key components necessary for tumor tissue acquisition. This proposal is a collaboration between scientists, lung cancer physicians, pathologists, and the IUSCCC Translational Research Core. Tumor tissue collected will be used for protein and gene analysis and RNA, whole exome sequencing in addition to the establishment of SCLC. This research is part of a discovery project in which biological and molecular markers of SCLC will be identified.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active SCLC Diagnosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biospecimen Collection | Procedure | Lung, liver, skin, subcutaneous metastases, and blood specimens may be collected via rapid autopsy within 10 hours of expiration. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Determining the Feasibility of the Creation of a Rapid Autopsy Program at IUSCCC for SCLC through enrollment and sample collections | 5 years | |
| Utilization of Tissue to Better Understand the Complex Biology of SCLC | Utilize tissue obtained from rapid autopsies to generate novel patient derived xenograft models and tumor cell lines, in addition to RNA, whole exome and whole genome sequencing, protein extraction to better understand the complex biology of SCLC and set up an infrastructure to develop relevant clinical models that will allow the development of better therapies. | 5 years |
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Inclusion Criteria:
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Any patient with active SCLC being seen at IUSCCC clinics.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gabby Kline, BA | Contact | (317) 278-2514 | gabkline@iu.edu | |
| Shadia I. Jalal, MD | Contact | 317-274-3589 | sjalal@iu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Shadia I. Jalal, MD | Indiana University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Indiana University Melvin and Bren Simon Comprehensive Cancer Center | Recruiting | Indianapolis | Indiana | 46202 | United States |
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| ID | Term |
|---|---|
| D055752 | Small Cell Lung Carcinoma |
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
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| Roudebush VA Medical Center | Recruiting | Indianapolis | Indiana | 46202 | United States |
|
| Sidney and Lois Eskenazi Hospital | Recruiting | Indianapolis | Indiana | 46202 | United States |
|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |