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The goal of this clinical trial is to learn about goal-directed LCVP based on hypovolemic phlebotomy (HP) in laparoscopic hepatectomy. The main questions it aims to answer are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hypovolemic phlebotomy (HP) | Experimental | patients in this group undergoing laparoscopic hepatectomy was performed with goal-directed LCVP based on hypovolemic phlebotomy (HP) |
|
| Control | No Intervention | patients in this group undergoing laparoscopic hepatectomy was performed with LCVP but no hypovolemic phlebotomy (HP) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hypovolemic phlebotomy | Procedure | hypovolemic phlebotomy was performed after induction of anesthesia and before the star of parenchymal division, with a goal-directed low central venous pressure drop to 5mmHg. |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of allogeneic red blood cell products transfusion | The primary end point of the study was the proportion of patients who required transfusion of allogeneic red blood cell products during laparoscopic hepatectomy or at any time during the hospitalization during the index admission. | From date of operation until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 12 months. |
| Measure | Description | Time Frame |
|---|---|---|
| The volume of Phlebotomy | From the start of operation until the end of operation. | |
| The volume of Intraoperative blood loss | From the start of operation until the end of operation (during the operation). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shijiang Liu, MD | Contact | +862568303569 | liushijiang@jsph.org.cn | |
| Yue Wang | Contact | +862568136360 | jsphkjwy@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Shijiang Liu, MD | The First Affiliated Hospital with Nanjing Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Nanjing Medical University | Recruiting | Nanjing | Jiangsu | 210029 | China |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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|
| The volume of Allogeneic transfusion (perioperative) | From date of operation until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 12 months. |
| The volume of Allogeneic transfusion (postoperative) | From the end of operation until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 12 months. |
| The volume of Allogeneic transfusion (intraoperative) | From the start of operation until the end of operation. |
| The volume of Fresh frozen plasm (FFP) transfusion | From date of operation until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 12 months. |
| The volume of Platelets transfusion | From date of operation until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 12 months. |
| The volume of Albumin transfusion | From date of operation until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 12 months. |
| Perioperative lowest concentration of Hb | From the start of operation until the date of discharge from hospital or date of death from any cause, whichever came first. assessed up to 12 months. |
| Pre-transection central venous pressure (CVP), (basic CVP) | From the start of anesthesia induction until the star of operation. |
| Lowest central venous pressure (CVP) | From the start of operation until the end of operation (during the operation). |
| time of pringle maneuver | From the start of operation until the end of operation. |
| number of pringle maneuver | how many patients have the pringle maneuver | From the start of operation until the end of operation. |
| operating time | From the start of operation until the end of operation. |
| The proportion of laparoscopic hepatectomy converted to open liver resection | From the start of operation until the end of operation. |
| Length of stay | From date of hospitalization until the date of discharge from hospital or date of death from any cause, whichever came first. assessed up to 12 months |
| Number of Participants with postoperative complications (overall) | From date of operation until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 1 months. |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |