Effects of Vitamin D Status and Multiple Mega-dose Supplementation on Health Care Disparities in Perioperative Patients With Hepatocellular Carcinoma Receiving Hepatectomy

Effects of Vitamin D Status and Multiple Mega-dose Supplementation on Health Care Disparities in Perioperative Patients With Hepatocellular Carcinoma Receiving Hepatectomy

High concentrations of parathyroid hormone (PTH) are common in patients with hepatocellular carcinoma (HCC). This study is aimed to investigate effects of vitamin D status and its multiple mega-dosage supplementation on PTH and clinical outcomes in HCC patients before and after hepatectomy. It's a single-center, prospective, parallel, double-blind, placebo-controlled study for 120 eligible subjects. The subjects will receive consecutively 3-day intervention treatments from 7th day before surgery. 30-day postoperative mortality, postoperative complications, and laboratory data will be evaluated.

Inclusion Criteria:

• 1. ≥ 20-year HCC subjects receiving laparoscopic hepatectomy
• 2.Sign the informed consent

Exclusion Criteria:

• 1. Using estrogen drugs, bisphosphonates, or drugs for bone disease.
• 2. Consume calcium tablets within 2 weeks before operation
• 3. Sarcoidosis, multiple myeloma
• 4. Pregnant women or plan to become pregnant within 3 months after surgery
• 5. Autoimmune hepatitis (AIH)
• 6. Early liver recurrence
• 7. Used to participate in other clinical trials