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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Topical 6-Gingerol Group | Active Comparator | Group I Will include 14 patients receiving topical ginger extract 1% four times per day (after every meal and before going to bed) for eight weeks (Zakaria et al., 2020). |
|
| Topical Steroid Group | Active Comparator | Group II Will include 14 patients receiving topical steroid (triamcinolone acetonide 0.1%) four times per day for eight weeks (Laeijendecker et al., 2006) In the fourth and eighth weeks, topical anti-fungal will be applied by a third-party medical personnel to avoid 2ry candidiasis for this group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 6-Gingerol | Drug | 6-gingerol gel will be applied locally to the participants suffering from oral lichen planus |
|
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of Ginger Muco-bioadhesive Gel in Management of Oral Lichen Planus | Analysis of 6-Gingerol gel in Management of Oral Lichen Plauns using Immunohistochemistry | Baseline |
Not provided
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marwa Shehata, Bachelor | Contact | +201007493498 | marwa_dnt@hotmail.com | |
| Ola Ezzat, Ass. Pro. | Contact |
Not provided
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19277504 | Background | Ahn SI, Lee JK, Youn HS. Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol. Mol Cells. 2009 Feb 28;27(2):211-5. doi: 10.1007/s10059-009-0026-y. Epub 2009 Feb 20. | |
| 17950516 | Background | Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol. 2008 Feb;46(2):409-20. doi: 10.1016/j.fct.2007.09.085. Epub 2007 Sep 18. |
| Label | URL |
|---|---|
| Related Info | View source |
Not provided
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| ID | Term |
|---|---|
| D017676 | Lichen Planus, Oral |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D008010 | Lichen Planus |
| D017512 | Lichenoid Eruptions |
Not provided
Not provided
| ID | Term |
|---|---|
| C007845 | gingerol |
| D014222 | Triamcinolone Acetonide |
| ID | Term |
|---|---|
| D014221 | Triamcinolone |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
Not provided
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Group I Will include 14 patients receiving topical ginger extract 1% four times per day (after every meal and before going to bed) for eight weeks (Zakaria et al., 2020).
Group II Will include 14 patients receiving topical steroid (triamcinolone acetonide 0.1%) four times per day for eight weeks (Laeijendecker et al., 2006)
Not provided
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The study is designed to be a prospective randomized double blind 2 parallel arms controlled clinical trial.
| Triamcinolone Acetonide 0.1% Oromucosal Paste | Drug | Triamcinolone Acetonide 0.1% gel will be applied locally to the participants suffering from oral lichen planus |
|
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| Related Info | View source |
| Related Info | View source |
| Related Info | View source |
| D017444 |
| Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |