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| Name | Class |
|---|---|
| Women's Hospital School Of Medicine Zhejiang University | OTHER |
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This study aims to collect serum samples from healthy non-pregnant women, pregnant women with and without Gestational Diabetes Mellitus (GDM). We will analyze the metabolite changes among the three groups using clinical metabolomics and identify potential biomarkers and metabolic pathways. This study will provide scientific evidence for early clinical diagnosis, prevention, control, and treatment research of GDM.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GDM group | Pregnant women aged 20-40 with positive oral glucose tolerance test (OGTT) results at 24-28 weeks. |
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| non-GDM group | Pregnant women aged 20-40 with negative OGTT results at 24-28 weeks. |
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| Control group | Healthy non-pregnant women aged 20-40. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Specimen samples and baseline data collection | Other | The remaining serum samples from routine blood tests of subjects will be collected (without additional blood collection), with a serum sample size of approximately 1 mL per subject. The samples will be pre-processed and stored at ultra-low temperatures. At the same time, clinical baseline data of subjects will be collected from outpatient or inpatient medical records, including but not limited to age, height, weight, blood pressure, and gestational age. |
| Measure | Description | Time Frame |
|---|---|---|
| Content of serum metabolomics | Based on non-targeted metabolomics technology, the metabolites in serum were comprehensively detected. Differential metabolites were screened using multivariate statistical analysis. Then quantitatively detect the content of these metabolites to find the differential metabolites with predictive ability for GDM. | Second trimester (24-28 gestational weeks) |
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Inclusion Criteria:
Exclusion Criteria:
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This study aims to recruit pregnant women undergoing routine prenatal examinations and healthy women undergoing routine physical examination.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| LI Lu, Dr. | Contact | 0571-88208596 | luciali@zju.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Women's Hospital School Of Medicine Zhejiang University | Recruiting | Hangzhou | Zhejiang | 310006 | China |
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| ID | Term |
|---|---|
| D004194 | Disease |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Specimen samples and baseline data collection | Other | The remaining serum samples from routine blood tests of subjects will be collected (without additional blood collection), with a serum sample size of approximately 1 mL per subject. The samples will be pre-processed and stored at ultra-low temperatures. At the same time, clinical baseline data of subjects will be collected from outpatient or inpatient medical records, including but not limited to age, height, weight, blood pressure, and gestational age. |
|
| Specimen samples and baseline data collection | Other | The remaining serum samples from routine blood tests of subjects will be collected (without additional blood collection), with a serum sample size of approximately 1 mL per subject. The samples will be pre-processed and stored at ultra-low temperatures. At the same time, clinical baseline data of subjects will be collected from outpatient or inpatient medical records, including but not limited to age, height, weight, blood pressure, and gestational age. |
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