Clinical Outcomes in Patients With Infection by Resistant Microorganism

Clinical Outcomes in Patients With Infection by Resistant Microorganism

The goal of this individual patient data meta-analysis is to estimate the attributed and the associated health burden related to bloodstream infections, pneumonia, skin and soft tissue infections, surgical site infections and urinary tract infections, caused by target drug-resistant pathogens, in high income countries.

The main question[s] it aims to answer are:

• Are common infections caused by drug-resistant pathogens associated with an increased health burden, when compared with individuals with the same infection caused by a susceptible strain (attributed burden)?
• Are common infections caused by drug-resistant pathogens associated with an increase health burden, when compared with individuals without the infection under study (associated burden)?

Inclusion Criteria:

• Individuals of all ages
• Individuals with hospital acquired, community acquired, or healthcare associated infections
• Individuals treated at hospital level, community, or long-term care facilities
• Individuals with the targeted pathogen, resistance phenotype, and infection site combinations under study

Exclusion Criteria:

• Individuals with infections in the following systems: central nervous system, genital system, pelvic infections and head and neck infections
• Individuals with the following specific primary infections: endocarditis, upper respiratory tract infections, lung abscess
• Individuals with bacterial infections not included in the table of pathogens of interest, polymicrobial infections except for intraabdominal infections, fungal infections, parasitic infections, viral infections, mycobacterial infections, sexually transmitted diseases, and zoonotic infections