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| Name | Class |
|---|---|
| Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | OTHER |
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The goal of this individual patient data meta-analysis is to estimate the attributed and the associated health burden related to bloodstream infections, pneumonia, skin and soft tissue infections, surgical site infections and urinary tract infections, caused by target drug-resistant pathogens, in high income countries.
The main question[s] it aims to answer are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Drug-resistant pathogen | Individuals of all ages with the target pathogen, resistance phenotype, and infection site combinations as follows:
|
| |
| Drug-susceptible pathogen | Individuals of all ages with the target pathogen, susceptible phenotype, and infection site combinations as follows:
|
| |
| No infection | Individuals of all ages without the infection under study |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pathogen resistant phenotype | Other | Drug resistant phenotype of the target pathogen under study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Death any time after infection, during the follow-up time of the original study. | Through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with ICU admission | Need for an admission in ICU setting for more than 24 hours after infection onset. | Through study completion, an average of 1 year |
| Number of participants with clinical cure |
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Inclusion Criteria:
Exclusion Criteria:
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Individuals of all ages with the target pathogen, resistance phenotype, and infection site combinations as follows:
Individuals of all ages with the same infection caused by the target drug-susceptible pathogen
Individuals of all ages without the infection under study
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| Name | Affiliation | Role |
|---|---|---|
| Jesús RodrÃguez-Baño, MD PhD | Unidad ClÃnica de Enfermedades Infecciosas, MicrobiologÃa. Hospital Universitario Virgen Macarena | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitario Virgen Macarena | Seville | Spain |
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Absence of symptoms after completion of an antibiotic treatment course.
| Through study completion, an average of 1 year |
| Number of participants with microbiological cure | No isolation of the causal microorganisms after completion of an antibiotic treatment course. | Through study completion, an average of 1 year |
| Number of participants with recurrence of infection | Infection with the same organism after more than two weeks of the initial infection. | Through study completion, an average of 1 year |
| Number of participants with superinfection | Other infections different from the one under assessment. | Through study completion, an average of 1 year |
| Number of participants with cognitive impairment / disability | Impairment is any temporal or permanent loss of function; disability is a restriction or inability to perform a normal activity resulting from an impairment. Assessed using Center for Epidemiologic Studies Depression Scale (CES-D), Mini-Mental State Examination (MMSE) or Trail Making Test (TMT). | Through study completion, an average of 1 year |
| ID | Term |
|---|---|
| D011014 | Pneumonia |
| D018805 | Sepsis |
| D014552 | Urinary Tract Infections |
| D002481 | Cellulitis |
| D013530 | Surgical Wound Infection |
| D013203 | Staphylococcal Infections |
| D004927 | Escherichia coli Infections |
| D000151 | Acinetobacter Infections |
| D011552 | Pseudomonas Infections |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D012874 | Skin Diseases, Infectious |
| D013492 | Suppuration |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D014946 | Wound Infection |
| D011183 | Postoperative Complications |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D004756 | Enterobacteriaceae Infections |
| D016905 | Gram-Negative Bacterial Infections |
| D045828 | Moraxellaceae Infections |
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