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| ID | Type | Description | Link |
|---|---|---|---|
| R01MH121509 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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The objective of this study is to examine the effect of transcranial magnetic stimulation (TMS) on the prefrontal cortex and posterior parietal cortex.
The Comprehensive Control Task (CCT) was designed to examine hierarchical control in a single, well-controlled factorial task. On each trial, participants view a letter surrounded by a colored shape at a particular screen location. Color cues the relevant feature, letter or location, for a block of trials. The first trial of a block requires a decision of whether the stimulus is the first position of a circular sequence (sequence start). Subsequent trials require a decision of whether the viewed stimulus follows the previous stimulus in a circular sequence (sequence 1-back). The letter sequence (T-A-B-L-E-T) and spatial sequence (Top-Bottom Right-Left-Right-Bottom Left-Top) are difficulty-matched.
Shape cues the task to perform. Squares indicate the standard baseline task, and each block begins and ends with baseline trials. Different shapes indicate sub-tasks. In Switching blocks, shape-switches (e.g. from square to circle or circle to square) cue the sequence start task. Shape-repeats cue the sequence 1-back task. In Planning blocks, triangle shapes indicate that the stimulus can be ignored (automatic "no" response). All the while, the last square-shaped stimulus must be retained as a reference for the next square-shaped stimulus. Finally, in Dual blocks, diamond shapes indicate switching (sequence start) and also planning. The reversion back to square shapes requires sequence matching to the distal, previous square.
The design is factorial with stimulus-domain x contextual control x temporal control orthogonally manipulated. Full details of the CCT have been previous described in Nee & D'Esposito, 2016; 2017.
The focus in this study will be comparison of FPl-TMS, MFG-TMS, and S1-TMS in an interleaved fMRI-TMS-fMRI design. The logic is to test the apical status of the FPl/MFG through the extent to which TMS impacts other PFC areas and behavior.
Each experiment will begin with 1 session of the CCT with fMRI to localize PFC targets. Each participant will then perform 3 counter-balanced sessions wherein a different site will be targeted by TMS followed immediately by fMRI on the CCT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FPl-TMS | Experimental | Transcranial magnetic stimulation to the lateral frontal pole. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold. |
|
| MFG-TMS | Experimental | Transcranial magnetic stimulation to the middle frontal gyrus. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold. |
|
| S1-TMS | Active Comparator | Transcranial magnetic stimulation to the primary somatosensory cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial magnetic stimulation | Device | Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
|
| Measure | Description | Time Frame |
|---|---|---|
| PFC-PPC Effective Connectivity | effective connectivity among areas of the prefrontal and posterior parietal cortex in the blood oxygenation level dependent (BOLD) signal assessed with functional magnetic resonance imaging (fMRI) [note, this measure has no units, but effective connectivity is a rate measure, so is expressed in Hertz] | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
| PFC-PPC Activation | blood oxygenation level dependent (BOLD) signal in areas of the prefrontal and posterior parietal cortex assessed with functional magnetic resonance imaging (fMRI) [note, this measure has no units] | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
| Measure | Description | Time Frame |
|---|---|---|
| Temporal Control Performance (Error Rate) | behavioral performance (error rate) on conditions involving temporal control in the comprehensive control task | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
| Contextual Control Performance (Error Rate) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Derek E Nee, PhD | Florida State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Florida State University Psychology Department Building | Tallahassee | Florida | 32303 | United States | ||
Behavioral and imaging data will be shared
Within a year following publication of findings
Behavioral and imaging data will be accessible from NIMH Data Archive
After enrollment, participants complete 1) a baseline functional MRI scan to determine targets for transcranial magnetic stimulation, and 2) motor thresholding to determine intensity of transcranial magnetic stimulation. Participants are not assigned to arms if they cannot perform the task inside the MRI scanner (e.g. due to claustrophobia) or if they cannot tolerate transcranial magnetic stimulation.
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| ID | Title | Description |
|---|---|---|
| FG000 | MFG-TMS Then FPl-TMS Then S1-TMS | Transcranial magnetic stimulation to the middle frontal gyrus then lateral frontal pole then primary somatosensory cortex. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| FG001 | MFG-TMS Then S1-TMS Then FPl-TMS | Transcranial magnetic stimulation to the middle frontal gyrus then primary somatosensory cortex then lateral frontal pole. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| FG002 | FPl-TMS Then MFG-TMS Then S1-TMS | Transcranial magnetic stimulation to the lateral frontal pole then middle frontal gyrus then primary somatosensory cortex. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| FG003 | FPl-TMS Then S1-TMS Then MFG-TMS | Transcranial magnetic stimulation to the lateral frontal pole then primary somatosensory cortex then middle frontal gyrus. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| FG004 | S1-TMS Then MFG-TMS Then FPl-TMS | Transcranial magnetic stimulation to primary somatosensory cortex then middle frontal gyrus then lateral frontal pole. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| FG005 | S1-TMS Then FPl-TMS Then MFG-TMS | Transcranial magnetic stimulation to primary somatosensory cortex then lateral frontal pole then middle frontal gyrus. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | MFG-TMS Then FPl-TMS Then S1-TMS | Transcranial magnetic stimulation to the middle frontal gyrus then lateral frontal pole then primary somatosensory cortex. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | PFC-PPC Effective Connectivity | effective connectivity among areas of the prefrontal and posterior parietal cortex in the blood oxygenation level dependent (BOLD) signal assessed with functional magnetic resonance imaging (fMRI) [note, this measure has no units, but effective connectivity is a rate measure, so is expressed in Hertz] | Participants were included in analysis if they (1) met an 85% overall accuracy on the behavioral task prior to the intervention, (2) completed all three study arms and (3) did not exceed a root mean squared framewise displacement of 0.25, a measure of movement during scans. | Posted | Mean | Standard Error | Hertz | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
|
From enrollment until end of participation, up to 6 weeks
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | FPl-TMS | Transcranial magnetic stimulation to the lateral frontal pole. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold. |
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| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Scalp discomfort | Skin and subcutaneous tissue disorders | Non-systematic Assessment |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Derek Nee | Florida State University | 8506441963 | dnee@fsu.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jul 1, 2024 | Feb 3, 2026 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jun 13, 2023 | Feb 3, 2026 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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behavioral performance (error rate) on conditions involving contextual control in the comprehensive control task |
| baseline, pre-intervention and immediately after intervention (t minutes to 1 hour post-TMS) |
| Temporal x Contextual Control Performance (Error Rate) | behavioral performance (error rate) of the interaction of temporal and contextual control in the comprehensive control task | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
| Temporal Control Performance (Reaction Time) | behavioral performance (reaction time in milliseconds) on conditions involving temporal control in the comprehensive control task | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
| Contextual Control Performance (Reaction Time) | behavioral performance (reaction time in milliseconds) on conditions involving contextual control in the comprehensive control task | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
| Temporal x Contextual Control Performance (Reaction Time) | behavioral performance (reaction time in milliseconds) on the interaction between temporal control and contextual control in the comprehensive control task | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
| FSU MRI Facility |
| Tallahassee |
| Florida |
| 32306 |
| United States |
| TMS Intolerance |
|
| BG001 | MFG-TMS Then S1-TMS Then FPl-TMS | Transcranial magnetic stimulation to the middle frontal gyrus then primary somatosensory cortex then lateral frontal pole. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| BG002 | FPl-TMS Then MFG-TMS Then S1-TMS | Transcranial magnetic stimulation to the lateral frontal pole then middle frontal gyrus then primary somatosensory cortex. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| BG003 | FPl-TMS Then S1-TMS Then MFG-TMS | Transcranial magnetic stimulation to the lateral frontal pole then primary somatosensory cortex then middle frontal gyrus. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| BG004 | S1-TMS Then MFG-TMS Then FPl-TMS | Transcranial magnetic stimulation to primary somatosensory cortex then middle frontal gyrus then lateral frontal pole. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| BG005 | S1-TMS Then FPl-TMS Then MFG-TMS | Transcranial magnetic stimulation to primary somatosensory cortex then lateral frontal pole then middle frontal gyrus. Each visit consists of 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold to one target. transcranial magnetic stimulation: Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance. |
| BG006 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Full Range | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| OG001 | MFG-TMS | Transcranial magnetic stimulation to the middle frontal gyrus. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold. |
| OG002 | S1-TMS | Transcranial magnetic stimulation to the primary somatosensory cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold. |
|
|
|
| Primary | PFC-PPC Activation | blood oxygenation level dependent (BOLD) signal in areas of the prefrontal and posterior parietal cortex assessed with functional magnetic resonance imaging (fMRI) [note, this measure has no units] | Participants were included in analysis if they (1) met an 85% overall accuracy on the behavioral task prior to the intervention, (2) completed all three study arms and (3) did not exceed a root mean squared framewise displacement of 0.25, a measure of movement during scans. | Posted | Mean | Standard Error | No Unit | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
|
|
|
|
| Secondary | Temporal Control Performance (Error Rate) | behavioral performance (error rate) on conditions involving temporal control in the comprehensive control task | Participants were included in analysis if they (1) met an 85% overall accuracy on the behavioral task prior to the intervention, and (2) completed all three study arms. | Posted | Mean | Standard Error | Percentage of errors | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
|
|
|
|
| Secondary | Contextual Control Performance (Error Rate) | behavioral performance (error rate) on conditions involving contextual control in the comprehensive control task | Participants were included in analysis if they (1) met an 85% overall accuracy on the behavioral task prior to the intervention, and (2) completed all three study arms. | Posted | Mean | Standard Error | Percent Errors | baseline, pre-intervention and immediately after intervention (t minutes to 1 hour post-TMS) |
|
|
|
|
| Secondary | Temporal x Contextual Control Performance (Error Rate) | behavioral performance (error rate) of the interaction of temporal and contextual control in the comprehensive control task | Participants were included in analysis if they (1) met an 85% overall accuracy on the behavioral task prior to the intervention, and (2) completed all three study arms. | Posted | Mean | Standard Error | Percentage Errors | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
|
|
|
|
| Secondary | Temporal Control Performance (Reaction Time) | behavioral performance (reaction time in milliseconds) on conditions involving temporal control in the comprehensive control task | Participants were included in analysis if they (1) met an 85% overall accuracy on the behavioral task prior to the intervention, and (2) completed all three study arms. | Posted | Mean | Standard Error | Milliseconds | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
|
|
|
|
| Secondary | Contextual Control Performance (Reaction Time) | behavioral performance (reaction time in milliseconds) on conditions involving contextual control in the comprehensive control task | Participants were included in analysis if they (1) met an 85% overall accuracy on the behavioral task prior to the intervention, and (2) completed all three study arms. | Posted | Mean | Standard Error | Milliseconds | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
|
|
|
|
| Secondary | Temporal x Contextual Control Performance (Reaction Time) | behavioral performance (reaction time in milliseconds) on the interaction between temporal control and contextual control in the comprehensive control task | Participants were included in analysis if they (1) met an 85% overall accuracy on the behavioral task prior to the intervention, and (2) completed all three study arms. | Posted | Mean | Standard Error | Milliseconds | baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS) |
|
|
|
|
| 0 |
| 37 |
| 0 |
| 37 |
| 4 |
| 37 |
| EG001 | MFG-TMS | Transcranial magnetic stimulation to the middle frontal gyrus. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold. | 0 | 34 | 0 | 34 | 1 | 34 |
| EG002 | S1-TMS | Transcranial magnetic stimulation to the primary somatosensory cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold. | 0 | 35 | 0 | 35 | 0 | 35 |
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|
| Overall BOLD in Contextual Control Subsystem |
|
| Overall BOLD in Sensorimotor Control Subsystem |
|
| Temporal Control BOLD in Temporal Control Subsystem |
|
| Temporal Control BOLD in Contextual Control Subsystem |
|
| Temporal Control BOLD in Sensorimotor Control Subsystem |
|
| Contextual Control BOLD in Temporal Control Subsystem |
|
| Contextual Control BOLD in Contextual Control Subsystem |
|
| Contextual Control BOLD in Sensorimotor Control Subsystem |
|
| Temporal x Contextual Control BOLD in Temporal Control Subsystem |
|
| Temporal x Contextual Control BOLD in Contextual Control Subsystem |
|
| Temporal x Contextual Control BOLD in Sensorimotor Control Subsystem |
|
| Overall BOLD Change from Baseline |
|
| Overall BOLD in Temporal Control Subsystem Change from Baseline |
|
| Overall BOLD in Contextual Control Subsystem Change from Baseline |
|
| Overall BOLD in Sensorimotor Control Subsystem Change from Baseline |
|
| Temporal Control BOLD in Temporal Control Subsystem Change from Baseline |
|
| Temporal Control BOLD in Contextual Control Subsystem Change from Baseline |
|
| Temporal Control BOLD in Sensorimotor Control Subsystem Change from Baseline |
|
| Contextual Control BOLD in Temporal Control Subsystem Change from Baseline |
|
| Contextual Control BOLD in Contextual Control Subsystem Change from Baseline |
|
| Contextual Control BOLD in Sensorimotor Control Subsystem Change from Baseline |
|
| Temporal x Contextual Control BOLD in Temporal Control Subsystem Change from Baseline |
|
| Temporal x Contextual Control BOLD in Contextual Control Subsystem Change from Baseline |
|
| Temporal x Contextual Control BOLD in Sensorimotor Control Subsystem Change from Baseline |
|
| 0.633 |
| Superiority |
Interaction of visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS) and subsystem (temporal, contextual, sensorimotor control) on overall BOLD activation. |
| ANOVA | 0.606 | Superiority | Interaction of visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS) and temporal control on BOLD activation. |
| ANOVA | 0.171 | Superiority | Interaction of visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS) and contextual control on BOLD activation. |
| ANOVA | 0.001 | Superiority | Interaction of visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), temporal control, and contextual control on BOLD activation. |
| ANOVA | 0.002 | Superiority | Interaction of visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), temporal control, and subsystem (temporal, contextual, sensorimotor) on BOLD activation. |
| ANOVA | 0.004 | Superiority | Interaction of visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), contextual control, and subsystem (temporal, contextual, sensorimotor) on BOLD activation. |
| ANOVA | 0.165 | Superiority | Interaction of visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), temporal control, contextual control, and subsystem (temporal, contextual, sensorimotor) on BOLD activation. |
| ANOVA | 0.888 | Superiority | The main effect of intervention arm (FPl-iTBS, MFG-iTBS, S1-iTBS) on overall BOLD activation. |
| ANOVA | 0.668 | Superiority | Interaction of intervention arm (FPl-iTBS, MFG-iTBS, S1-iTBS) and subsystem on overall BOLD activation. |
| ANOVA | 0.874 | Superiority | Interaction of intervention arm (FPl-iTBS, MFG-iTBS, S1-iTBS) and temporal control on BOLD activation. |
| ANOVA | 0.124 | Superiority | Interaction of intervention arm (FPl-iTBS, MFG-iTBS, S1-iTBS) and contextual control on BOLD activation. |
| ANOVA | 0.03 | Superiority | Interaction of intervention arm (FPl-iTBS, MFG-iTBS, S1-iTBS), temporal control and contextual control on BOLD activation. |
| ANOVA | 0.406 | Superiority | Interaction of intervention arm (FPl-iTBS, MFG-iTBS, S1-iTBS), temporal control and subsystem (temporal, contextual, sensorimotor) on BOLD activation. |
| ANOVA | 0.168 | Superiority | Interaction of intervention arm (FPl-iTBS, MFG-iTBS, S1-iTBS), contextual control and subsystem (temporal, contextual, sensorimotor) on BOLD activation. |
| ANOVA | 0.148 | Superiority | Interaction of intervention arm (FPl-iTBS, MFG-iTBS, S1-iTBS), temporal control, contextual control and subsystem (temporal, contextual, sensorimotor) on BOLD activation. |
| Difference between high and low temporal control sub-task trial error rate |
|
| Difference between high and low temporal control return trial error rate |
|
| Difference between high and low temporal control trials error rate relative to baseline |
|
| Difference between high and low temporal control sub-task trial error rate relative to baseline |
|
| Difference between high and low temporal control return trial error rate relative to baseline |
|
| 0.909 |
| Non-Inferiority |
Interaction between visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), and temporal control on error rate |
| ANOVA | 0.602 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS) and temporal control on error rate |
| ANOVA | 0.985 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), and temporal control on error rate |
| Difference between high and low contextual control sub-task trial error rate |
|
| Difference between high and low contextual control return trial error rate |
|
| Difference between high and low contextual control trial error rate relative to baseline |
|
| Difference between high and low contextual control sub-task trial error rate relative to baseline |
|
| Difference between high and low contextual control return trial error rate relative to baseline |
|
| 0.046 |
| Superiority |
Interaction between visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), and contextual control on error rate |
| ANOVA | 0.098 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS) and contextual control on error rate |
| ANOVA | 0.007 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), and contextual control on error rate |
| Interaction contrast of temporal and contextual control on error rate on sub-task trials |
|
| Interaction contrast of temporal and contextual control on error rate on return trials |
|
| Interaction contrast of temporal and contextual control on error rate relative to baseline |
|
| Interaction contrast of temporal and contextual control on error rate on sub-task trials vs baseline |
|
| Interaction contrast of temporal and contextual control on error rate on return trials vs baseline |
|
| 0.818 |
| Superiority |
Interaction between visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), temporal control, and contextual control on error rate |
| ANOVA | 0.972 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS), temporal control and contextual control on error rate |
| ANOVA | 0.878 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), temporal control, and contextual control on error rate |
| Difference between high and low temporal control sub-task trial reaction time |
|
| Difference between high and low temporal control return trial reaction time |
|
| Difference between high and low temporal control trial reaction time relative to baseline |
|
| Difference between high and low temporal control sub-task trial reaction time relative to baseline |
|
| Difference between high and low temporal control return trial reaction time relative to baseline |
|
| 0.364 |
| Superiority |
Interaction between visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), and temporal control on reaction time |
| ANOVA | 0.611 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS) and temporal control on reaction time |
| ANOVA | 0.389 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), and temporal control on reaction time |
| Difference between high and low contextual control sub-task trial reaction time |
|
| Difference between high and low contextual control return trial reaction time |
|
| Difference between high and low contextual control trial reaction time relative to baseline |
|
| Difference between high and low contextual control sub-task trial reaction time relative to baseline |
|
| Difference between high and low contextual control return trial reaction time relative to baseline |
|
| 0.534 |
| Superiority |
Interaction between visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), and contexutal control on reaction time |
| ANOVA | 0.194 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS) and contextual control on reaction time |
| ANOVA | 0.746 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), and contextual control on reaction time |
| Interaction contrast of temporal control x contextual control sub-task trials on reaction time |
|
| Interaction contrast of temporal control x contextual control return trials on reaction time |
|
| Interaction contrast of temporal control x contextual control trials on reaction time vs baseline |
|
| Interaction contrast of temporal control x contextual control sub-task trials on RT vs baseline |
|
| Interaction contrast of temporal control x contextual control return trials on RT vs baseline |
|
| 0.33 |
| Superiority |
Interaction between visit (Baseline, FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), temporal control, and contextual control on reaction time |
| ANOVA | 0.663 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS), temporal control and contextual control on reaction time |
| ANOVA | 0.611 | Superiority | Interaction between intervention (FPl-iTBS, MFG-iTBS, S1-iTBS), phase (subtask, return), temporal control, and contextual control on reaction time |