The purpose of this study is to evaluate whether or not mindfulness-based interventions/MBIs may help reduce chronic pain in participants who have cancer-related chronic pain. MBIs are therapeutic programs that use mindfulness meditation practices to help people focus on the present moment, as well as encourage acceptance of thoughts, emotions, and body sensations. The researchers think that an MBI treatment called Mindfulness-oriented Recovery Enhancement (MORE) may help people who are experiencing cancer-related chronic pain.

Inclusion Criteria:

• English speaking
• Age ≥ 18 years or older
• A history of cancer with no restrictions placed on type of cancer
• Determined to be either no-evidence of disease or stable oncological disease by referring or study physicians/advanced practice providers
• Having a pain (musculoskeletal, generalized, or neuropathic) rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week
• Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days
• Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: MORE or WLC
• Ability to attend video-call session and a quiet/private location

Exclusion Criteria:

• Active suicidality or schizophrenia
• Plan to initiate palliative radiation or interventional pain procedure within the next 12 weeks
• Cognitive impairment preventing completing PRO independently or participate in virtual MORE as evaluated by study clinicians

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.