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During the pandemic of COVID-19, studies reporting a high incidence of barotrauma, both pneumothorax but also pneumomediastinum, in patients with critical COVID-19. If this is complications of the respiratory support used to treat patients hypoxemia or if it is a direct consequence of COVID-19 damaging the lung tissue is not known.
The aim of this study is to investigate the incidence and type barotrauma, if there is an association between barotrauma and level of respiratory support used in the intensive care unit, and if barotrauma is associated with worse outcome compared to patients without barotrauma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Respiratory support by an open system |
| ||
| Respiratory support by non-invasive mechanical ventilation |
| ||
| Respiratory support by invasive mechanical ventilation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Open system | Procedure | Oxygen delivered on open system, for example high flow nasal cannula or low flow oxygen by nasal cannula or face mask |
|
| Measure | Description | Time Frame |
|---|---|---|
| Barotrauma | Pneumothorax, pneumomediastinum, pneumatocele or subcutaneous emphysema as verified by radiology | 28 days from ICU admission |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with critical COVID-19 admitted to an intensive care unit at Södersjukhuset, Stockholm, Sweden, March 2020 to May 2021.
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| Name | Affiliation | Role |
|---|---|---|
| Sandra Jonmarker, Ph D | Stockholm South General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Södersjukhuset | Stockholm | 11883 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39936659 | Derived | Jensen AL, Litorell J, Grip J, Dahlberg M, Joelsson-Alm E, Jonmarker S. A descriptive, retrospective single-centre study of air-leak syndrome in intensive care unit patients with COVID-19. Acta Anaesthesiol Scand. 2025 Mar;69(3):e14582. doi: 10.1111/aas.14582. |
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Individual participants data for our patients is protected by law and can therefore not be made available for other researchers.
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D001469 | Barotrauma |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D063087 | Noninvasive Ventilation |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
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| Non-invasive mechanical ventilation | Procedure | Respiratory support by for example continues or bilevel positive airway pressure |
|
| Invasive mechanical ventilation | Procedure | Respiratory support delivered through endotracheal tube or tracheostomy |
|
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D014947 | Wounds and Injuries |