Postoperative Hypofractionated Intensity-modulated Radiotherapy Endometrial Cancer

Postoperative Hypofractionated Intensity-modulated Radiotherapy Endometrial Cancer: A Prospective Phase II Trial (POHIM_EM Trial)

To investigate the non-inferiority of disease-free survival in women who received hypofractionated intensity-modulated whole pelvic radiation therapy (2.5 Gy x 16 fractions) after curative surgery for stage III endometrial cancer.

Inclusion Criteria:

• histologically confirmed endometrioid type endometrial cancer
• completion of hysterectomy and surgical staging
• pathologically confirmed FIGO stage III
• ECOG performance status 0 or 1
• adjuvant chemotherapy was done or planned

Exclusion Criteria:

• presence of distant metastasis
• previous history of pelvic radiotherapy
• severe and unstable medical condition
• previous history of other carcinoma except for thyroid cancer, skin cancer, and endometrial cancer