The objectives of this study are to evaluate efficacy and safety of artificial saliva containing cumin and ginger extract in head and neck cancer patients with xerostomia.

There are 52 patients in this study. They are divided into 2 groups which are artificial saliva containing cumin and ginger extract group (test group) 26 patients and placebo group 26 patients. The patients spray the sample into the mouth 3 times/day for 14 day. Amount of saliva, pH of saliva, xerostomia questionnaires, WHO Oral Mucositis Grading Scale, quality of life, adverse events, and satisfaction were assessed.

Inclusion Criteria:

• Age more than 18 years
• Head and neck cancer with xerostomia
• 6 months post radiation
• Willing to participate in this study

Exclusion Criteria:

• Sialolith or Sjogren's syndrome
• Uncontrolled cancer
• Using artificial saliva more than 2 weeks
• Taking Pilocarpine or cevimeline more than 2 weeks
• Allergic to cumin, ginger, xylitol, and glycerin
• History of other oral mucosal diseases
• Pregnancy and lactation