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Pilot trial to determine diagnostic efficacy of post-reperfusion troponin kinetics in detection of hemorrhagic myocardial infarction
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| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic Threshold | Levels of markers in hemorrhagic infarct vs. non-hemorrhagic infarct | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Peak levels of serum troponin-I | peak levels of serum troponin-I in hemorrhagic infarct vs non-hemorrhagic infarct | 48 hours |
| Area under the curve (AUC) for serum troponin-I | area under the curve post-MI for troponin-I |
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Inclusion Criteria:
Exclusion Criteria:
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The study population consists of individuals aged 18 to 80 who have been diagnosed with acute ST-elevation myocardial infarction (STEMI) and are scheduled for emergency percutaneous coronary intervention (PCI).
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| Name | Affiliation | Role |
|---|---|---|
| Keyur P Vora, MD FACC | Faculty | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IU Methodist Hospital | Indianapolis | Indiana | 46202 | United States | ||
| Synergy Cardiovascular Research Center, Synergy Superspecialty Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40858097 | Derived | Vora KP, Kalra A, Shah CD, Bhatt K, Kumar A, Pandya T, Poptani V, Chan SF, Singh D, Jambunathan N, Subramanian R, Youssef K, Kanakasabai S, Finney R, Desai A, Kreutz RP, Kovacs RJ, Raman SV, Bhatt DL, Dharmakumar R. In-Hospital Mortality in Hemorrhagic Myocardial Infarction. NEJM Evid. 2025 Sep;4(9):EVIDoa2400294. doi: 10.1056/EVIDoa2400294. Epub 2025 Aug 26. |
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| ID | Term |
|---|---|
| D000072657 | ST Elevation Myocardial Infarction |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| 48 hours |
| Hemorrhagic infarct size | as determined by cardiac MRI | 48 hours |
| Hemorrhagic infarct volume | as determined by cardiac MRI | 48 hours |
| Hemorrhagic infarct microvascular obstruction | as determined by cardiac MRI | 48 hours |
| Hemorrhagic infarct area at risk | as determined by cardiac MRI | 48 hours |
| Rajkot |
| Gujarat |
| India |
| D014652 |
| Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |