The present study is aimed to explore the treatment effect from the intake of probiotic Lactobacillus crispatus M247 in the improvement of clinical and psychological aspects in women undergoing homologous level 2 ART procedures.

The use of assisted reproductive technology (ART) has increased dramatically worldwide due to the continuous rise in infertility rates; for these reasons an increasing number of couples undertake the path of ART, even though this is difficult journey, with uncertain outcomes and possible medical risks, both physical and psychological.

In this study the investigators aim to explore the hypothesis that recreating a favorable vaginotype through the intake of the probiotic Lactobacillus crispatus M247 can have a positive effect in achieving pregnancy in cryopreserved cycles as well as a positive relationship between vaginal, endometrial (still unknown), gut and oral microbiota.

Inclusion Criteria:

• Women undergoing homologous level 2 assisted reproductive technology (ART) procedures
• Cryopreserved oocytes
• D3 embryos
• D5 blastulae
• Age 18-45

Exclusion Criteria:

• Presence of submucous uterine myomas.
• Uterine malformations.

The study is applicable only to women