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| Name | Class |
|---|---|
| Afyonkarahisar Health Sciences University | OTHER |
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The study aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) applications on early wound healing after gingivectomy and gingivoplasty surgery. In this randomized controlled single-blind study, gingivectomy and gingivoplasty surgeries were performed on 46 patients. The postoperative I-PRF-applied surgery areas were compared with control regions. The surgical areas were stained with Mira-2 tone and evaluated in the ImageJ program. Wound healing was evaluated by using the Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index. Vascular endothelial growth factor (VEGF) and fibroblast growth factor 10 (FGF-10) concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA). The seven-day Visual Analog Scale was used to assess pain level.
Considering the results found, I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test group | Active Comparator | I-PRF is placed on the wound site after a gingivectomy with the conventional method and closed with a periodontal dressing |
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| control group | Placebo Comparator | closure of the wound site with only a periodontal dressing after a gingivectomy with the conventional method. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ä°njectable platelet rich fibrin | Other | I-PRF is a type of platelet-rich fibrin (PRF) product obtained from the patient's own blood. PRF is a kind of tissue regeneration product of blood, rich in platelets, growth factors and cellular components. |
| Measure | Description | Time Frame |
|---|---|---|
| effects of I-PRF on wound healing and epithelialization | I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations. | seven months |
| Measure | Description | Time Frame |
|---|---|---|
| effects of biochemical markers on wound healing | In order to see the effects of biochemical markers on wound healing, gingival crevicular fluid samples should be taken at more frequent intervals. | seven months |
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Inclusion Criteria:
(a) systemically healthy patients ages 15-40 years, (b) pregnancy or lactation, (c) patients with chronic inflammatory gingival overgrowth in the mandibular and maxillary anterior area, (d) no attachment and bone loss, (e) not using immunosuppressive agents, systemic corticosteroids, chemotherapy, and/or radiotherapy drugs taken or prescribed 2 months before the study attempt, which may affect the study results, wound healing, and coagulation mechanism, and (f) patients with sufficient oral hygiene.
Exclusion Criteria:
(a) patients who had a history of periodontal treatment in the last 6 months, (b) smokers and alcohol users, those who used drugs that may cause gingival enlargement in the last 6 months, (c) patients with poor communication, and (d) patients who did not attend controls at designated times.
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| Name | Affiliation | Role |
|---|---|---|
| şeyma ÇARDAKCI BAHAR, Lecturer | University of Health Sciences; Ankara, Turkey | Principal Investigator |
| Nebi Cansın KARAKAN, Asst. Prof. | Faculty of Dentistry Afyonkarahisar University of Health Sciences, Afyonkarahisar, Turkey | Study Director |
| Ayhan VURMAZ, Assoc. Prof. | Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Health Sciences; Ankara, Turkey | Ankara | 06010 | Turkey (Türkiye) |
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1 year after the study was published
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| ID | Term |
|---|---|
| C043309 | proliferation regulatory factors, human urine |
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| Gingivectomy anad gingivoplasty | Procedure | leveling and regulation of the gingiva |
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