Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Clinical Immunological Department, Rigshospitalet | UNKNOWN |
| The Danish Blood Donor Study | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
The aim of the project is to investigate whether or not there are any difference in cardiometabolic outcomes in individuals with high or low levels of c-aAb against interleukin-6 (IL-6).
The study is the first to investigate individuals with extreme amounts of c-aAb levels against IL-6 and to contribute with knowledge on a possible new phenotype.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High IL-6 c-aAb | Experimental | Individuals with top percentile IL-6 c-aAb |
|
| Low IL-6 c-aAb | Experimental | Individually matched controls with low IL-6 c-aAb |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral Glucose Tolerance Test | Other | 75g oral glucose tolerance test, sampled over three hours |
|
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory markers | IL-6 plasma levels, plasma IL-6 c-aAb levels | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Whole-body glucose metabolism | Plasma levels of: Insulin | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Whole-body glucose metabolism | Plasma levels of: C-peptide | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Whole-body glucose metabolism | Plasma levels of: Glucose | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Whole-body glucose metabolism | Plasma levels of: GLP-1 | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Whole-body glucose metabolism | Plasma levels of: GIPR | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Cardiovascular risk markers | Lipids | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Torben Hansen, PhD | Contact | 20565301 | +45 | torben.hansen@sund.ku.dk |
| Rasmus T Jensen, MSc | Contact | 24429252 | +45 | rasmus.tanderup@sund.ku.dk |
| Name | Affiliation | Role |
|---|---|---|
| Torben Hansen, PhD | University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Frederiksberg Hospital | Recruiting | Frederiksberg | 2000 | Denmark |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
Not provided
Not provided
Groups defined by autoantibodies status (high or low)
Not provided
Not provided
Not provided
Not provided
| Cycling test | Other | 2 hours of moderate activity level cycling |
|
| Cardiovascular risk markers | Triglyceride | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Cardiovascular risk markers | Blood pressure | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Cardiovascular risk markers | Epicardial adipose tissue | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Difference in exercise response | 2-hour Lactate | Measurements over a two-hour cycling test, and one hour of recovery |
| Difference in exercise response | 2-hour epinephrine | Measurements over a two-hour cycling test, and one hour of recovery |
| Difference in exercise response | 2-hour norepinephrine | Measurements over a two-hour cycling test, and one hour of recovery |
| Difference in exercise response | Peak IL-6 | Measurements over a two-hour cycling test, and one hour of recovery |
| Metabolic response during exercise | 2-hour glucose | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Metabolic response during exercise | 2-hour glucagon | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Metabolic response during exercise | 2-hour insulin | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Metabolic response during exercise | 2-hour lipids | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Metabolic response during exercise | Triglyceride | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery |
| Metabolic assessment of the liver | Liver fat content from MRI-scanning, and HOMA-IR | An MRI-scanning withinn four weeks of the oral glucose tolerance test |
| Metabolic assessment of the liver | HOMA-IR | An MRI-scanning withinn four weeks of the oral glucose tolerance test |
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |