Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

Identifying Challenges to Healthy Aging in Persons With HIV Age 50 and Older

The primary objective of this study is to identify and characterize frailty and pre-frailty in persons age 50 and older living with human immunodeficiency virus (HIV) followed by the Atrium Health Wake Forest Baptist Infectious Diseases Specialty Clinics (IDSC).

The study will implement electronic medical record-based screening for frailty (eFI), further characterize frailty using comprehensive geriatric screening, and offer a customized activity and nutrition plan to a subset of participants. Participation in phlebotomy for research biomarkers of aging is optional. The study also seeks to validate the electronic medical record embedded electronic frailty index (eFI) for the prediction of adverse outcomes in aging persons with HIV, characterize the symptoms of pre-frailty and frailty in persons followed in the IDSC, and assess the acceptability and efficacy of a customized activity and nutrition intervention targeting frailty. The study will also correlate research biomarkers of aging with aging symptoms in a subset of participants.

Inclusion Criteria:

• Person living with human immunodeficiency virus (HIV)
• Age ≥50 years
• Followed by the Atrium Health Wake Forest Baptist Infectious Diseases Specialty Clinic (IDSC)
• Eligible for Ryan White Program
• Able to provide informed consent
• Pre-frail or frail by electronic frailty index (eFI)

Exclusion Criteria:

• Age <50 years (study designed to characterize frailty in aging persons with HIV)
• Unable to complete the required assessments or questionnaires