Efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome

Efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome

To evaluate efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome

To evaluate efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome by 6 minute walking distance and oxygen consumption.

Inclusion Criteria:

• Diagnosis with COPD by GOLD guideline criteria (Post bronchodilator FEV1/FVC < 0.7 or < LLN) with post bronchodilator FEV1 = 30-80%
• Diagnosis with obstructive sleep apnea with AHI > 15 event/hr. (Moderate OSA or more)
• Age between 40-80 years
• Stable disease prior to inclusion.

Exclusion Criteria:

• Diagnosis with > 50% of central sleep apnea event
• History of COPD exacerbation during the past 8 week prior to inclusion.
• Subjects who cannot perform spirometry test or walking test
• Subjects with recording history of chronic heart failure, significant arrhythmias, acute myocardial infarction, moderate to severe mitral or aortic valve disease and pulmonary hypertension.
• Subjects with interstitial lung disease.
• Subjects with neuromuscular disease.
• Subjects with morbid obesity (BMI >/=35)
• Subjects with chronic respiratory infection.
• Subjects with chronic CO2 retension (PaCO2 >/= 45 from arterial blood gas analysis) or Transcutaneous CO2 during sleep test >/= 45 or Serum bicarbonate level > 27
• Subjects with acute or active respiratory infecton during 2 week prior to inclusion.