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The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI. TMS is a noninvasive method used to modulate brain activity via changing magnetic fields applied over the surface of the scalp.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active TMS | Experimental | Participants will receive single-session administration of TMS. Functional MRI will be acquired before and immediately after the intervention. |
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| Placebo TMS | Placebo Comparator | Participants will also receive single session administration of placebo TMS (at least two days apart from the day of the active TMS). Functional MRI will be acquired before and immediately after the intervention. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active TMS | Device | Continuous theta burst stimulation (cTBS) will be administered over the left inferior parietal lobule for approximately 3 minutes at 120% of the resting motor threshold. |
| Measure | Description | Time Frame |
|---|---|---|
| Working memory accuracy | Accuracy at high memory loads during performance of the Sternberg Item Recognition Paradigm will be assessed before and after the TMS interventions. | 2 hours |
| Reaction time during working memory | Reaction time during performance of the Sternberg Item Recognition Paradigm will be assessed before and after the TMS interventions. | 2 hours |
| Resting state functional connectivity between the left inferior parietal lobule and the regions of the frontoparietal control network | Functional connectivity between left inferior parietal lobule and dorsolateral prefrontal cortex will be computed during resting state acquired before and after the TMS interventions. | 2 hours |
| Resting state functional connectivity within the default mode network | Functional connectivity between left inferior parietal lobule and other regions of the default mode network (including the posterior cingulate cortex and the medial prefrontal cortex) will be computed during resting state acquired before and after the TMS interventions. | 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Martinos Center for Biomedical Imaging | Charlestown | Massachusetts | 02129 | United States |
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| ID | Term |
|---|---|
| D011618 | Psychotic Disorders |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
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| Placebo TMS | Device | Placebo TMS will be applied over the left inferior parietal lobule for approximately 3 minutes. |
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