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| ID | Type | Description | Link |
|---|---|---|---|
| 5K08EY035037-03 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Eye Institute (NEI) | NIH |
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The goals of this study are to 1) use EEG steady-state visual evoked potentials as a noninvasive measure of the neuroplasticity induced by repetitive transcranial magnetic stimulation (rTMS), 2) use visual contrast detection paradigms as a behavioral measure of rTMS effects, and 3) to investigate how visual spatial attention augments or suppresses the neuroplastic impact of rTMS. Participants will observe visual stimuli on a screen while allocating their attention to different parts of the visual field and making responses when they observe changes in the visual stimuli. rTMS is performed to visual cortex using MRI-retinotopy neuronavigation. Then the visual task paradigm is performed again.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Visual Cortex, 1 Hz rTMS, Attended | Experimental |
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| Visual Cortex, 1 Hz rTMS, Unattended | Experimental |
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| Visual Cortex, 10 Hz rTMS, Attended | Experimental |
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| Visual Cortex, 10 Hz rTMS, Unattended | Experimental |
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| Visual Cortex, Sham, Attended | Sham Comparator |
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| Visual Cortex, Sham, Unattended | Sham Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| repetitive transcranial magnetic stimulation | Device | Repetitive TMS targeted by neuronavigation to left lower visual field of primary visual cortex. Randomized to 10 Hz or 1 Hz on different treatment days. Stimulation at 110% of phosphene threshold, or 110% resting motor threshold if phosphenes not detectable. 1 Hz: 1000 pulses total over 1000 seconds. 10 Hz: 1000 pulses over 10 10 second pulse trains, with 50 second intertrain intervals |
| Measure | Description | Time Frame |
|---|---|---|
| post-rTMS change in ssVEP Response Amplitude | Change in ssVEP contrast-response amplitude after rTMS | 60 minutes |
| post-rTMS change in visual contrast perceptual sensitivity | change in visual psychometric threshold across contrasts after rTMS | 60 minutes |
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Inclusion Criteria:
Exclusion Criteria:
Those with a contraindication for MRIs (e.g. implanted metal)
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| Name | Affiliation | Role |
|---|---|---|
| Ryan Ash, MD, PhD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Stanford | California | 94306 | United States |
The results of this research will be made available via publication in scientific journals and through scientific meetings where our findings are reported. Publication of data shall occur during the project, if appropriate, or at the end of the project, consistent with normal scientific practices. All publications will be made publicly available consistent with NIH policies. Research data, which documents, supports and validates research findings, will be made available after the main findings from the final research data set have been accepted for publication.
Data will be available on reasonable request following completion of data collection.
see above
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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Cross-over: 1 Hz vs 10 Hz vs sham rTMS; stimulation to attended or unattended hemisphere
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Participant is blind to the rTMS target hemisphere, the rTMS stimulation parameters, and the objective of the study
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