Transcranial current stimulation (tCS) has been extensively studied due to its potential of selectively stimulate brain regions in a non-invasive way. However, classic stimulation paradigms are often applied in an open loop configuration, without considering the effects on the underlying brain activity.

Recent studies suggest that when alternating current are used, it would be beneficial to phase lock the stimulation to the target brain wave of interest to achieve selective temporal stimulation, allowing for better control over the stimulation effects.

This study aims at demonstrating a novel setup that allows for precise stimulation targeted in space and time. To achieve that, a combination of tCS and (EEG phased locked) closed-loop modality are used to obtain the required selectivity.

Inclusion Criteria:

• Signed informed consent
• Age between 18 and 64

Exclusion Criteria:

• Wounded or particular sensitive skin at areas of investigation. For example, skinrash, discoloration, scars, or open wounds
• Allergies to adhesive or dry electrodes or silver chloride
• Pregnant or lactating
• Any of the following symptoms (fever, tiredness, dry cough, aches and pains, nasal congestion, runny nose, sore throat, diarrhoea)
• Known neurological disorders
• Previous epileptic episodes
• Active implants such as pacemakers or brain stimulators
• Intracranial metal implants