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| Name | Class |
|---|---|
| Huashan Hospital | OTHER |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| First Affiliated Hospital of Fujian Medical University | OTHER |
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The goal of this prospective observational cohort study is to learn about treatment strategies for unruptured intracranial aneurysms in the Chinese population. The main questions it aims to answer are:
According to the treatment of all patients with unruptured intracranial aneurysm, they were divided into the following groups: 1. Conservative treatment group; 2. Intracranial aneurysm clipping group; 3. Coil embolization or stent-assisted coil embolization group; 4. Flow diversion group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intracranial aneurysm clipping group | Patients in Intracranial aneurysm clipping group receive neurosurgical clipping. |
| |
| Coil embolization or stent-assisted coil embolization group | Patients in coil embolization or stent-assisted coil embolization group receive coil embolization or stent-assisted coil embolization according to individualized condition. |
| |
| Flow diversion group. | Patients in flow diversion group receive flow diverters. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observation | Other | observation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Primary Outcome | Functional outcomes(modified Rankin Scale,mRS) at 2 years after treatment decision | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| MACCE events | Incidence of major adverse cardiovascular/cerebrovascular events (MACCE events) in patients with atherosclerotic heart disease within 1 year after treatment decision. | 1 years |
| cardiovascular/cerebrovascular events |
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Inclusion Criteria:
A. age > 18 years. B. at least one intracranial aneurysm needs to be treated by craniotomy, endovascular treatment or combined surgery.
C. patients' consent were obtained.
Exclusion Criteria:
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Patients with unruptured intracranial aneurysm
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| Name | Affiliation | Role |
|---|---|---|
| Wang shuo, M.D. | Beijing Tiantan Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Capital Medical University Affiliated Beijing Tiantan Hospital | Beijing | Beijing Municipality | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42241917 | Derived | Guo R, Wang K, Feng Y, Zheng K, Liu Q, Jiang P, Wu J, Wang S, Tong X. Different duration of dual antiplatelet therapy after endovascular treatment for unruptured intracranial aneurysms. J Clin Neurosci. 2026 Jun 4;152:112124. doi: 10.1016/j.jocn.2026.112124. Online ahead of print. | |
| 40181400 | Derived | Zheng K, Wen Z, Wang K, Mo S, Wu J, Chen X, Zhao B, Liu Q, Wang S. Treatment strategies for unruptured intracranial aneurysms in the Chinese population: China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA). Chin Neurosurg J. 2025 Apr 3;11(1):8. doi: 10.1186/s41016-025-00394-7. |
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| Shanxi Provincial People's Hospital |
| OTHER_GOV |
| Peking University First Hospital | OTHER |
| Peking University Third Hospital | OTHER |
| Beijing Chao Yang Hospital | OTHER |
| Beijing Friendship Hospital | OTHER |
| Beijing Hospital | OTHER_GOV |
| Anhui Provincial Hospital | OTHER_GOV |
| The First Affiliated Hospital of Anhui Medical University | OTHER |
| Binzhou Medical University | OTHER |
| The Second Affiliated Hospital of Dalian Medical University | OTHER |
| Xijing hospital of The fourth military medical university | UNKNOWN |
| Fujian Medical University Union Hospital | OTHER |
| The First Dongguan Affiliated Hospital of Guangdong Medical University | UNKNOWN |
| First Affiliated Hospital of Guangxi Medical University | OTHER |
| The First Affiliated Hospital of Guangzhou Medical University | OTHER |
| The second People's Hospital of Guiyang | UNKNOWN |
| The Affiliated Hospital Of Guizhou Medical University | OTHER |
| Guizhou Provincial People's Hospital | OTHER |
| Guilin Medical University, China | OTHER |
| National Center for Neurological Disorders (China) | UNKNOWN |
| First Affiliated Hospital of Harbin Medical University | OTHER |
| Changhai Hospital, Naval Medical University | UNKNOWN |
| The Second Affiliated Hospital of Hainan Medical University | OTHER |
| The Second Hospital of Hebei Medical University | OTHER |
| Wuhan TongJi Hospital | OTHER |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | OTHER |
| The First Hospital of Jilin University | OTHER |
| Guangzhou Red Cross Hospital | OTHER |
| Jiangnan University Medical Center | UNKNOWN |
| Xunxian People's Hospital | UNKNOWN |
| The Second Affiliated Hospital of Kunming Medical University | OTHER |
| First Affiliated Hospital of Kunming Medical University | OTHER |
| Lanzhou University Second Hospital | OTHER |
| The Southwest Hospital of Army Medical University | UNKNOWN |
| Second Affiliated Hospital of Nanchang University | OTHER |
| Nanfang Hospital, Southern Medical University | OTHER |
| The General Hospital of Eastern Theater Command | OTHER |
| Inner Mongolia People's Hospital | OTHER |
| General Hospital of Ningxia Medical University | OTHER |
| Qinghai People's Hospital | OTHER |
| The First Affiliated Hospital of Xiamen University | OTHER |
| Qilu Hospital of Shandong University | OTHER |
| Qilu Hospital of Shandong University (Qingdao) | OTHER |
| Qingdao Municipal Hospital | OTHER |
| The First Affiliated Hospital of Shanxi Medical University | OTHER |
| Shanghai Jiao Tong University Affiliated Sixth People's Hospital | OTHER |
| Ruijin Hospital | OTHER |
| RenJi Hospital | OTHER |
| Shenzhen Second People's Hospital | OTHER |
| The General Hospital of Northern Theater Command | OTHER |
| Xuanwu Hospital, Beijing | OTHER |
| West China Hospital | OTHER |
| Sichuan Provincial People's Hospital | OTHER |
| Sichuan Academy of Medical Sciences | OTHER |
| Second Affiliated Hospital of Soochow University | OTHER |
| The First Affiliated Hospital of Soochow University | OTHER |
| Tangshan Gongren Hospital | OTHER |
| Tianjin Huanhu Hospital | OTHER |
| Tianjin Medical University General Hospital | OTHER |
| First Affiliated Hospital Xi'an Jiaotong University | OTHER |
| Second People's Hospital of Tibet Autonomous Region | UNKNOWN |
| Tibet Autonomous Region People's Hospital | OTHER |
| Second Xiangya Hospital of Central South University | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| The Affiliated Hospital of Xuzhou Medical University | OTHER |
| Zhejiang University | OTHER |
| The Second Affiliated Hospital Zhejiang University School of Medcine | UNKNOWN |
| Chinese PLA General Hospital | OTHER |
| First Hospital of China Medical University | OTHER |
| Shengjing Hospital | OTHER |
| First Affiliated Hospital, Sun Yat-Sen University | OTHER |
| Chongqing General Hospital | OTHER |
| First Affiliated Hospital of Chongqing Medical University | OTHER |
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Incidence of cardiovascular/cerebrovascular events in 2 years after receiving different treatment strategies.
| 2 years |
| Cost | Costs associated with unruptured intracranial aneurysms within 2 years after treatment with different strategies. | 2 years |
| Aneurysm-related bleeding events | Incidence of aneurysmal-related bleeding events within 2 years after receiving different treatment strategies. | 2 years |
| Mortality associated with intracranial aneurysms | Mortality associated with intracranial aneurysms within 2 years after treatment with different strategies | 2 years |
| All-cause mortality | All-cause mortality of patients within 2 years after different treatment strategies. | 2 years |
| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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