Cerebral and Cognitive Markers of Treatment Resistance in... | NCT05843604

Studies
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

NCT05843604

Sponsor

Centre Hospitalier Henri Laborit

Status

Recruiting

Last Update Posted

Jan 13, 2026Actual

Enrollment

100Estimated

Phase

Not provided

Conditions

Interventions

Functional MRI

Countries

France

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Jan 2026

Overall Recruitment Status or Expanded Access Status

Recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jul 3, 2023Actual

Primary Completion Date

Jul 2027Estimated

Completion Date

Sep 2027Estimated

First Submitted Date

Apr 25, 2023

First Submission Date that Met QC Criteria

Apr 25, 2023

First Posted Date

May 6, 2023Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jan 12, 2026

Last Update Posted Date

Jan 13, 2026Actual

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

100Estimated

Label	Type	Description	Intervention Names
obsessive compulsive disorder patients			Other: Functional MRI
Control Patients			Other: Functional MRI

Name	Type	Description	Arm Group Labels	Other Names
Functional MRI	Other	Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task	Control Patients obsessive compulsive disorder patients

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Cerebral activity modification during N-back task	Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls	Day 1
Cerebral activity modification during Stroop task	Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls	Day 1
Cerebral activity modification during switching task (Monsell et Mizon task )	Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls	Day 1

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
Understand and accept the constraints of the study
Be a beneficiary or affiliated to a Health Insurance scheme

Exclusion Criteria:

Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
Have a serious intercurrent pathology
Being a pregnant woman
Being a woman of childbearing age without effective contraception.
Being hospitalized under duress or on an outpatient basis in a care program
Being under judicial protection (reinforced curatorship, guardianship)

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

70 Years

Standard Ages

AdultOlder Adult

Study Population

Patients will be recruited from the Clinical Research Unit of Poitiers. All volunteer patients included in this study will be included regardless of the degree of resistance to treatment or the severity of their disease. Patients will not be hospitalized for the duration of the study unless their condition requires it.

Healthy volunteers will be recruited locally by advertisement or through acquaintances, and will be matched to each patient based on age, gender, laterality, and education level. They must not have an acute pathology being treated, nor take psychotropic drugs, nor be followed in psychotherapy. In their history, we must not find hospitalization in a psychiatric environment or a psychiatric illness according to the M.I.N.I. version 5.0.0.

Sampling Method

Probability Sample