Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Inclusion Criteria:

• Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
• Understand and accept the constraints of the study
• Be a beneficiary or affiliated to a Health Insurance scheme

Exclusion Criteria:

• Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
• Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
• Have a serious intercurrent pathology
• Being a pregnant woman
• Being a woman of childbearing age without effective contraception.
• Being hospitalized under duress or on an outpatient basis in a care program
• Being under judicial protection (reinforced curatorship, guardianship)