The purpose of this study is to see how effective non-steroidal anti-inflammatory drugs (NSAIDs) are at controlling pain without side effects in participants after robotic-assisted partial nephrectomy.

Inclusion Criteria:

• Patients undergoing uncomplicated robotic assisted laparoscopic partial nephrectomy for renal mass at the University of Miami Hospital and Network Sites (Deerfield Beach, Plantation, Lennar (Coral Gables), and Kendal).
• Age 18-99.
• Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

• Allergy to NSAIDs
• Myocardial infarction or unstable angina within 12 months.
• Any history of coronary artery bypass graft surgery.
• History or active peptic ulcer disease, gastrointestinal (GI) bleeding, GI perforation. History of bleeding disorder. Glomerular filtration rate (GFR) < 60 mL/min/1.73m2 (Modification of Diet in Renal Disease (MDRD) equation).
• Taking any anti-platelet or anti-coagulation medications concurrently (e.g. warfarin, aspirin, clopidogrel, rivaroxaban etc.)
• Chronic opioid use (use within 12 weeks) or history of opioid use disorder.
• Solitary kidney.
• Pregnancy.
• Inability to give informed consent or unable to meet requirement of the study for any reason.

After study recruitment, the patient will be randomized to the NSAID group (group 1) vs. the no-NSAID group (group 2). Randomization will be masked until after the renorrhaphy is completed and the surgical team will administer versus not administer ketorolac based on group assignment.