Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Coblation is a unique method of delivering radio frequency energy to the soft tissue for applications in otolaryngology. It induces reduction of the inferior turbinate by vaporizing and destroying the soft erectile tissue. The volume reduction and tissue fibrosis are immediate and sustainable. Bleeding from the vascular capillary beds of the sinonasal mucosa compromises the surgical field and increases operative time and risk of complications. In this study we try to assist hemostasis with a multifaceted approach, including use of topical vasoconstrictors "phenylephrine" and systemic antifibrinolytic agent "tranexamic acid".
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| phenylephrine | Active Comparator | phenylephrine-soaked pack will be applied after induction of surgery and intubation. |
|
| tranexamic acid | Active Comparator | Single intravenous dose of tranexamic acid 15 mg/kg will be given in 100 mL normal saline over 10 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Topical Phenylephrine Solution | Drug | phenylephrine-soaked pack using the whole 5 ml of the solution provided with.5% phenylephrine will be applied after induction of surgery and intubation, 15 minutes before surgery. 100 ml of normal saline will be given. |
| Measure | Description | Time Frame |
|---|---|---|
| surgical field scale | the intraoperative surgical site bleeding using the surgical field scale as follows: 0 = No bleeding
| intraoperativel |
| Measure | Description | Time Frame |
|---|---|---|
| Volume of Blood loss | intraoperative | |
| Duration of surgery | the duration from induction of anesthesia till extubation | |
| Avoidance of postoperative nasal packing |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed A Mohammed, M.D. | Contact | 01060757593 | ahmedfotoh86@aun.edu.eg |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D016063 | Blood Loss, Surgical |
| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007431 | Intraoperative Complications |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| intravenous tranexamic acid | Drug | patients will receive intravenous Single dose of tranexamic acid 15 mg/kg in 100 mL normal saline over 10 minutes. Saline-soaked pack will be applied. |
|
if the patient can be spared from postoperatiove nasal pack inserted for controllling bleeding |
| immediately after the surgey |
| Intra-operative and Postoperative complications | Complications such as nausea, vomiting, hypotnsion, hypertension, hemorraghic or thrombotic manifestations for 24 hours | intraoperative and 24 hours postoperative |