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The goal of this clinical trial is to investigate whether intravenous injection of tilofiban can reduce microembolism in patients with unruptured intracranial aneurysms after Stent-Assisted Coil Embolization.The main questions it aims to answer are:
We aim to reduce microembolism in patients with unruptured intracranial aneurysms after Stent-Assisted Coil Embolization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The intervention group | Experimental | An intravenous bolus (6µg/kg) over a 3 min period and a maintenance dose of 0.1µg/kg/min for 18 hour were used in this group. |
|
| The control group | Active Comparator | The same dose of normal saline was used instead of tirofiban. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tirofiban | Drug | Intravenous administration of tirofiban |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Microembolism | Number of microembolism | Within 72 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of microembolism | The incidence of microembolism | Within 48 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Hemorrhage | The incidence of Hemorrhage | Within 48 hours after surgery |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hua Lu Lu Hua | Contact | 18761671021 | luhua@njmu.edu.cn | |
| Lei Mao Mao Lei | Contact | 13057658078 | 2165451550@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jiangsu Province Hospital | Recruiting | Nanjing | China |
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| ID | Term |
|---|---|
| D002532 | Intracranial Aneurysm |
| D000783 | Aneurysm |
| ID | Term |
|---|---|
| D020765 | Intracranial Arterial Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D000077466 | Tirofiban |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D014443 | Tyrosine |
| D024322 | Amino Acids, Aromatic |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
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The intervention group: An intravenous bolus (6µg/kg) over a 3 min period and a maintenance dose of 0.1µg/kg/min for 18 hour were used in this group.
The control group: The same dose of normal saline was used instead of tirofiban.
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Blinding all personnel who may interfere with the trial results, such as Participant, Care Provider, Investigator and Outcomes Assessor
| normal saline |
| Drug |
Intravenous administration of normal saline |
|
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |