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compare the effect of intravenous and epidural dexmetomidine as an adjuvant to local anesthetics in epidural labor analgesia in normal labor
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| plan group | Placebo Comparator | bupivacaine will be administered epidurally as a loading dose then epidural continuous infusion with 0.125 % bupivacaine at rate 10 ml will be a maintainance for analgesia .IV placebo (normal saline) infusion will be connected to each patient at a rate of 10 ml \hr. |
|
| epidural group | Active Comparator | 10 ml of 0.125 % buoivacaine with 0.5 µg\ml dexmetomidine as a loading dose then continuous epidural infusion of 0.125% bupivacaine with 0.5µ/ml dexmetomidine at a rate of 10 ml\hr will be used as maintainance . IV placebo (normal saline) infusion will be connected to each patient at a rate of 10 ml\hr |
|
| intravenous group | Active Comparator | continuous intravenous dexmetomidine infusion at rate of 0.5 µg / kg / hour in addition to same epidural infusion of 0.125% bupivacaine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine Injection [Precedex] | Drug | interventional drug will be administred either intravenously or epidurally |
|
| Measure | Description | Time Frame |
|---|---|---|
| pain relief | VAS score from 0 to 10 will be assesed | at 30 min after induction of block |
| pain relief | VAS score from 0 to 10 | on delivery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| mostafa S mansour, MD | Contact | 01225484055 | mostafa.said@med.menofia.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| mostafa M mansour, MD | Menoufia University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Menoufia University Hospitals | Recruiting | Shibīn al Kawm | Menoufia | 32513 | Egypt |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Bupivacaine Injection | Drug | intervention drug will be administred epidurally |
|
| D000813 |
| Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |