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Endotracheal intubation can induce laryngotracheal injury which results in narrowing of the airway due to edema of the glottis. This can increase the risk of development of post-extubation stridor (PES)
Ultrasound (US) is a useful and non-invasive tool for the evaluation of vocal cords and laryngeal morphology in intubated patients. The laryngeal air-column width (LACW), Laryngeal air column width difference (LACWD), and laryngeal air-column width ratio (LACWR) measured by ultrasound can potentially identify patients at risk of post-extubation stridor, in whom caution should be taken after extubation.
The cuff-leak test can predict successful extubation through using the difference between the expired tidal volume with the cuff inflated and with the cuff deflated; the higher the leak, the lower the likelihood that post-extubation stridor will occur.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control (C) group | Placebo Comparator | normal saline will be nebulized |
|
| Budesonide (B) group | Active Comparator | budesonide will be nebulized |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| budesonide | Drug | 2 ml nebulized budesonide (containing 1 mg) diluted in 3 ml of normal saline will be nebulized preoperatively |
|
| Measure | Description | Time Frame |
|---|---|---|
| Laryngeal air column width ratio | % | immediately before extubation |
| Measure | Description | Time Frame |
|---|---|---|
| The duration of nasal endotracheal intubation | min | Procedure (from nasal endotracheal intubation till extubation) |
| endotracheal tube insertion depth | cm |
| Measure | Description | Time Frame |
|---|---|---|
| Expiratory tidal volume immediate after intubation with the cuff deflated | ml | immediately after intubation |
| Expiratory tidal volume immediate before extubation with the cuff inflated | ml |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maha A AboZeid, MD | Contact | 02-01019216192 | mahazed@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maha Ahmed AboZeid | Recruiting | Al Mansurah | Mansoura | 35511 | Egypt |
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| ID | Term |
|---|---|
| D012135 | Respiratory Sounds |
| D007819 | Laryngeal Edema |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007818 | Laryngeal Diseases |
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| ID | Term |
|---|---|
| D019819 | Budesonide |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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Patients will be randomly allocated into two equal groups via opaque coded envelopes
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The preoperative aerosolized drug will be applied by an anesthetist who is not involved in further patient care
| normal saline | Drug | 5 ml normal saline will be nebulized preoperatively |
|
| immediately after intubation |
| The incidence of epistasis occurrence during nasotracheal intubation | 4-point verbal descriptor scale (0=no symptoms, 1=mild, 2=moderate, 3=severe) | immediately after intubation |
| Expiratory tidal volume immediate after intubation with the cuff inflated | ml | immediately after intubation |
| immediately before extubation |
| Expiratory tidal volume immediate before extubation with the cuff deflated | ml | immediately before extubation |
| cuff leak volume | ml | immediate after intubation and immediate before extubation |
| Laryngeal air column width | mm | before intubation |
| Laryngeal air column width | mm | immediate after intubation during the balloon-cuff inflation and during balloon-cuff deflation |
| Laryngeal air column width | mm | immediate before extubation during the balloon-cuff inflation and during balloon-cuff deflation |
| Laryngeal air column width difference | mm | immediate after intubation and immediate before extubation |
| incidence of postoperative sore throat, dysphonia, swallowing disorders or PES. | 4-point verbal descriptor scale (0=no symptoms, 1=mild, 2=moderate, 3=severe) | First postoperative day |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |