Treatment of Orthostatic Hypotension in SCI

Treatment of Orthostatic Hypotension in Individuals With Spinal Cord Injury

The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic hypotension, and levels of fatigue and comfort in hypotensive individuals with SCI.

Inclusion Criteria:

• traumatic spinal cord injury
• at least 12 months post injury
• injury level of C1-T6
• AIS A, B or C
• non-ambulatory
• non-ventilator

Exclusion Criteria:

• Active psychiatric disorder
• Stroke or cerebrovascular disease
• Alzheimer's Disease or dementia
• Unmanaged cardiac arrhythmias
• Concurrent systemic, hepatic, or renal disease
• Suspected or diagnosed malignancy
• Neurological disease other than SCI
• Self-reported history of three or more symptomatic episodes of AD per day