The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.

Hypothesis: In patients with hypertension working in the conditions of the Arctic shift, the combination of climatic and geographical factors and rotational expeditionary method of labor contributes to the increase in the left ventricular remodeling processes and leads to the formation of heart failure with preserved ejection fraction.

Inclusion Criteria:

• The patient signed the informed consent

Exclusion Criteria:

• Valvular pathology of the heart
• Past cardiac or cerebral complications
• Identified heart rhythm disturbances
• Coronary heart disease
• Patients with severe somatic pathology, whose prognostic survival rate does not exceed 1 year
• The presence of a mental disorder of organic origin

Зatients with hypertension of stages 1 and 2 and practically healthy individuals living in a temperate climate zone and carrying out an Arctic watch. Hypertension in the Arctic is characterized by faster target organ damage and worse prognosis.

Deidentified individual participant data (text, tables, figures, and appendices), underlying the results of the trial, will be shared with researchers to achieve the aims in the approved proposal.

Proposals may be submitted up to 36 months following publication of the results of the trial. After 36 months, the data will be available in the Center's data warehouse but without investigator support other than deposited metadata.

Information regarding submitting proposals and accessing data may be requested from the principal investigator by e-mail.