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| Name | Class |
|---|---|
| Shanghai Zhongshan Hospital | OTHER |
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In this case-only study, the investigators try to define a novel staging parameter, the Primary Tumor Burden Score (PTBS).
In this case-only study, the investigators try to define a novel staging parameter, the Primary Tumor Burden Score (PTBS), which will combine the proportion of residual primary tumor cells and pre-treatment pathological T stage (prepT stage). The investigators will also try to improve ypTNM stage by results of PTBS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training cohort | Training cohort will be used to find the best calculation and cut-off values for PTBS in ESCC after nCRT. |
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| Validation cohort | The study's conclusion will be verified in Zhongshan Hospital Xiamen branch. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nCRT | Procedure | ESCC patients that recieved surgery and nCRT. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Five-year survival of patients | The survival of the patients was recorded by follow-up for five years after surgery. | From surgery to the end of follow-up(at least 5 years later) |
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Inclusion Criteria:
- Neoadjuvant chemoradiotherapy and surgical resection of esophageal squamous cell carcinoma
Exclusion Criteria:
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Patients with ESCC undergoing nCRT at the Department of Thoracic Surgery, Zhongshan Hospital of Fudan University (training cohort), and the Department of Thoracic Surgery, Zhongshan Hospital Xiamen Branch (validation cohort), between January 2010 and February 2019 were reviewed. The inclusion criteria were (I) thoracic ESCC; (II) McKeown or Ivor-Lewis transthoracic approach; (III) locally advanced resectable tumor with cT3-4aNany staging treated with nCRT; (IV) no history of concomitant or prior malignancy.
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40758472 | Derived | Huang X, Jiang D, Sun T, Zhou G, Zeng Z, Zhang S, Lin M, Fan H, Jian Z, You R, Liu F, Wu M, Xu W, Tang H, Hou Y, Tan L. Primary Tumour Burden Score: A Novel Staging Parameter for Oesophageal Squamous Cell Carcinoma after Neoadjuvant Chemoradiotherapy. Eur J Cardiothorac Surg. 2025 Sep 2;67(9):ezaf254. doi: 10.1093/ejcts/ezaf254. |
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| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| D018307 | Neoplasms, Squamous Cell |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Patients' pathological sections
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |