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| ID | Type | Description | Link |
|---|---|---|---|
| R00HL148500 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The goal of this study is to understand the interaction between the circadian system and physical activity.
Participants will:
The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise A-B Intervention | Experimental | The Exercise A first, then the Exercise B intervention. |
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| Exercise B-A Intervention | Experimental | The Exercise B first, then the Exercise A intervention. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise intervention | Behavioral | Research participants will be assigned to two exercise conditions. |
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| Measure | Description | Time Frame |
|---|---|---|
| glucose level | mean glucose level after exercise session | 24-hour test period after exercise |
| mean arterial pressure | mean arterial pressure after exercise session | 24-hour test period after exercise |
| Measure | Description | Time Frame |
|---|---|---|
| insulin sensitivity index | Oral Minimal Model method estimates mean insulin sensitivity based on blood glucose and insulin levels from two mixed meal tests after exercise session | about 12 and 24 hours after exercise |
| beta-cell function index |
| Measure | Description | Time Frame |
|---|---|---|
| resting energy expenditure | energy expenditure will be measured at 1-2 hours interval by indirect calorimetry | 24-hour test period after exercise |
| respiratory exchange ratio | respiratory exchange ratio will be measured at 1-2 hours interval by indirect calorimetry |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jingyi Qian, PhD | Contact | 6175257423 | jqian@bwh.harvard.edu | |
| Vy Nguyen, B.S. | Contact | 617-525-0662 | vnguyen42@bwh.harvard.edu |
| Name | Affiliation | Role |
|---|---|---|
| Jingyi Qian, PhD | Brigham and Women's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brigham and Women's Hospital | Recruiting | Boston | Massachusetts | 02115 | United States |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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Oral Minimal Model method estimates mean beta-cell function based on blood glucose, insulin and c-peptide levels from two mixed meal tests after exercise session
| about 12 and 24 hours after exercise |
| total peripheral resistance | total peripheral resistance derived from BP waveform measured by finger plethysmography | 24-hour test period after exercise |
| autonomic nervous system activity | derived by time-domain heart rate variability analysis | 24-hour test period after exercise |
| 24-hour test period after exercise |