This research registry and repository was designed because the investigators want to learn about how to improve the health and quality of life of older adults.

The South Texas Aging Registry and Repository (STARR) is a database and specimen resource of community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. The goal is to assist in the inclusion of older adults in clinical research studies and to help to increase the quantity and quality of research relating to them. This registry and repository can be used for various purposes ranging from describing the natural history of aging, identifying risk factors for premature aging, and the real-world effectiveness of life-extending therapies. Collection and storage of biological samples and patient-reported data from of Individuals can help advance research and the development of new awareness of basic mechanisms that play a part in healthy aging or premature death.

Inclusion Criteria STARR:

-Age 18 years or older

Inclusion Criteria KAPP Sen TMC:

-Age 20 years and older

Exclusion Criteria STARR:

• Inability to provide informed consent
• Pregnancy

Exclusion Criteria KAPP Sen Tissue Mapping Center (TMC) Study:

• Diabetes
• Hypertension with end-organ damage
• BMI>30
• GFR<60 ml/min/1.73 m2
• Cardiovascular disease
• Pancreatitis
• Malignancy other than non-melanoma skin cancers
• Active, uncontrolled pulmonary, hepatic, infectious, gastrointestinal, endocrine, neurologic, or inflammatory disease.
• Chronic use of systemic steroids or use of agents with senolytic activity
• Any disease or condition considered to be exclusionary based on the clinical option and discretion of PI

Community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging.

New prospective studies and those involving interacting with human subjects: Participants/research volunteers who agree to be re-contacted will be matched with future studies which they are likely to qualify for based upon information provided by each STARR participant at the time of enrollment and which is gathered using provided samples.

KAPP Sen TMC will support the use of a web-based platform to connect and facilitate entering, sharing, and exchanging data among collaborates. Data will be exported to a web portal developed in conjunction with the CODCC where the research community can request access to molecular data and corresponding biospecimen data, such as clinical, demographic, and biospecimen handling data.

Requests from investigators to obtain data/specimens from the repository must be submitted in writing using an official repository request form, along with study protocol and documentation of appropriate approvals. Requests will be reviewed on a monthly basis by members of the Repository Executive Committee. Request to access data or specimens will be processed and entered into the Repository Log by the Repository Coordinator and submitted for review by the Executive Committee each month.