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| Name | Class |
|---|---|
| VBertoniMaluf | UNKNOWN |
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This retrospective monocentric study aims to investigate whether a low muscle mass at ICU admission and its loss over the ICU stay predicts mortality, and in what proportion we can counteract it by nutritional support.
The study hypothesis is that a low muscle mass at ICU admission, measured at the level of L3 on CT scans performed for clinical routine, and its change over the ICU stay predict the prognosis of the patient, especially the 30-day mortality, that it may at least be partly counteracted by nutritional support and that it is related with higher ICU and hospital costs.
The objectives of this retrospective study are to determine:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exposure(s) of interest : intensive care unit | Other | Low muscle mass is highly prevalent at hospital admission, and muscle mass generally decreases during hospital stay, especially in critically-ill patients. We would like to mesure muscle mas in critically ill patients and determine the association between outcomes. |
| Measure | Description | Time Frame |
|---|---|---|
| 30-day mortality | Association between skeletal muscle index (SMI) at the L3 vertebra level (psoas + abdominal wall muscles + paraspinal muscles), measured from 48 hours before to 96 hours after ICU admission, with 30-day mortality. | 30-day mortality between January 1st 2010 and December 31st 2022. |
| Measure | Description | Time Frame |
|---|---|---|
| Association of baseline body composition at ICU admission with other outcomes | Association of Skeletal muscle area (SMA), SMAH (Skeletal muscle area/height), SMD (Skeletal muscle density), IMAT (intermuscular and intramuscular adipose tissue), visceral and subcutaneous adipose tissue at the L3 vertebra level with 30-day mortality Determination of cut-off points of SMI, by sex, below which there is an increased risk of 30-day mortality Added value of body composition to ICU severity scores to predict 30-day mortality Association of baseline SMI, SMA, SMAH, SMD, intermuscular, visceral and subcutaneous adipose tissue at the L3 level, with ICU and hospital mortality and LOS, 30-day ICU readmission, duration of mechanical ventilation and infections |
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Inclusion Criteria:
Adults ≥ 18 yrs, hospitalized in the ICU of the HUG between January 1st 2010 and December 31st 2022 and Abdominal, or thoraco-abdominal CT scan measured 48 hours before to 96 hours after ICU admission in the HUG
Identical as for the associations of baseline body composition with clinical outcomes and At least one additional CT performed during the hospital stay
Exclusion Criteria:
CT scans of low quality or CT scans performed outside of the HUG or Presence of a documented refusal
Additionnally: oral nutrition, because we cannot assess the quantity and composition of oral intakes retrospectively
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Adults ≥ 18 yrs, hospitalized in the ICU of the HUG between January 1st 2010 and December 31st 2022
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| Name | Affiliation | Role |
|---|---|---|
| Laurence Genton, MD | University Hospital, Geneva | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laurence Genton | Geneva | Canton of Geneva | 1211 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40602605 | Derived | Genton L, Bertoni Maluf VA, Herrmann FR, Prado CM, de Watteville A, Dupertuis YM, Collet TH, Platon A, Heidegger CP. Obesity is associated with lower 30-day mortality in critically ill patients: A retrospective study of over 5400 patients. Clin Nutr ESPEN. 2025 Oct;69:37-44. doi: 10.1016/j.clnesp.2025.06.046. Epub 2025 Jun 30. |
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IPD Sharing Plan Description has not been decided.
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| 30-day |
| Association of baseline SMI at the L3 vertebra level vs. other locations to predict outcomes | Associations of SMI at the L3 vertebra level with SMI at the other locations Associations of SMI at the other locations with ICU and hospital mortality and LOS, 30-day ICU readmission, duration of mechanical ventilation and infections Comparison of the associations between muscle mass measured at the different anatomical locations and mortality in order to determine the best prognostic location | Day 1 to day 30 |
| Association of body composition changes with outcomes | Association of changes in SMI, SMA, SMAH, SMD, IMAT, visceral and subcutaneous adipose tissue with 30-day mortality, ICU and hospital mortality and LOS, 30-day ICU readmission, duration of mechanical ventilation and infections Added value of changes in body composition to changes in ICU severity scores to predict 30-day mortality | Day 30 |
| Association of body composition changes with nutritional support | Association of changes in energy coverage and changes in body composition Association of changes in protein coverage and changes in body composition | Day 30 |
| Association of muscle loss with medico-economical parameters | Association of baseline muscle mass and muscle loss in the ICU with ICU and hospital costs Association of muscle loss in the ICU with level of nursing workload | Day 30 |