Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity
Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity
Memantine is a drug for the management of Alzheimer's Disease (AD) due to its promising neuroprotective properties. We hypothesize that Memantine possesses a beneficial role against chemotherapy-induced neuronal damages.
Inclusion Criteria:
histologically confirmed diagnosis of stage III colorectal cancer performance status < 2 according to Eastern Cooperative Oncology Group (ECOG) score adequate renal function (glomerular filtration rate ≥ 90)
Exclusion Criteria:
preexisting neuropathic or brain disorders, a previous use of chemotherapeutic agents including oxaliplatin use of drugs reported to have neuroprotective role