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| Name | Class |
|---|---|
| Hospital Universitario Virgen Macarena | OTHER |
| Hospitales Universitarios Virgen del Rocío | OTHER |
| Hospital Universitario Torrecárdenas | OTHER |
| Hospital Universitario Poniente |
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Stroke is the leading cause of long-term disability and the second most common cause of death worldwide. Currently, the protocols require the imaging techniques at the hospitals to differ ischemic strokes with large vessel occlusion (LVO) from others. In this study, a duplex POC will be used in combination with an APP to identify LVO ischemic strokes in a 800 patients'cohort with pre-hospital and in-hospital blood samples.
Stroke is the leading cause of long-term disability and the second most common cause of death worldwide, accounting for around 6.7 million deaths each year. The burden of stroke due to illness, disability and early death is set to double within the next 15 years due to an ageing population. Currently, imaging techniques are required to differentiate ischemic strokes with large vessel occlusion (LVO) from others. Since those neuroimages cannot be easily done at a pre-hospital level, our objective is to develop a simple point-of-care test (POC) to differentiate between both ischemic strokes during the acute phase, which will allow in the future an earlier thrombectomy treatment and an improvement of the patient outcomes significantly. For that, the investigators will recruit a 800 patients' cohort with pre-hospital and in-hospital blood samples by a multiplex POC for the biomarker measurement using an APP in combination with clinical data to identify LVO ischemic strokes. Finally, an interim analysis is planned when 400 patients are recruited.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre-hospital and in-hospital patients | Patients recruited at the ambulance (ARM A) and at the hospital (ARM B). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Large Vessel Occlusion Biomarkers Test | Device | Duplex Point of Care test to measure the concentration of biomarkers associated to Large Vessel Occlusion in blood samples used in combination with an APP. |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the diagnosis accuracy of the algorithm LVOCheck (Specificity and sensibility) |
| 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Viability of the implement of the tool at a pre-hospital environment |
| 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with stroke code activated will be recruited at a pre-hospital and hospital environment.
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| Name | Affiliation | Role |
|---|---|---|
| Ana Barragán Prieto | Hospital Universitario Virgen Macarena | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Complejo Hospitalario Universitario Albacete | Albacete | Spain | ||||
| Hospital Universitario Poniente |
Individual participant data (IPD) might be included in a publication. Specific data set are not determined yet.
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| UNKNOWN |
| Hospital Clínico Universitario Lozano Blesa | OTHER |
| Hospital Miguel Servet | OTHER |
| Hospital Universitario Royo Villanova | UNKNOWN |
| Hospital General San Jorge | UNKNOWN |
| Hospital San Pedro de Logroño | OTHER |
| Hospital Clínico Universitario de Valladolid | OTHER |
| Hospital Universitario La Fe | OTHER |
| Complejo Hospitalario Universitario de Albacete | OTHER |
| Hospital de Medina del Campo | UNKNOWN |
| Hospital General Río Carrión | UNKNOWN |
| Hospital General de Segovia | OTHER |
| Hospital del Rio Hortega | OTHER |
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| Almería |
| Spain |
| Hospital Universitario Torrecárdenas | Almería | Spain |
| Hospital General San Jorge | Huesca | Spain |
| Hospital San Pedro | Logroño | Spain |
| Hospital General Río Carrión | Palencia | Spain |
| Hospital General de Segovia | Segovia | Spain |
| Hospital Universitario Virgen Macarena | Seville | Spain |
| Hospital Universitario Virgen Rocío | Seville | Spain |
| Hospital La Fe | Valencia | Spain |
| Hospital Clínico de Valladolid | Valladolid | Spain |
| Hospital de Medina del Campo | Valladolid | Spain |
| Hospital Universitario Río Hortega | Valladolid | Spain |
| Hospital Clínico Universitario Lozano Blesa | Zaragoza | Spain |
| Hospital Miguel Servet | Zaragoza | Spain |
| Hospital Royo Villanova | Zaragoza | Spain |
| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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