Ambulatory Versus Inpatient Initiation of Home Mechanical Ventilation

Ambulatory Versus Inpatient Initiation of Home Non-invasive Mechanical Ventilation in Patient With Amyotrophic Lateral Sclerosis: a Prospective, Noninferiority Randomized Controlled Trial (The NIB-study)

The purpose of this investigation is to see if outpatient initiation of noninvasive home mechanical ventilation combined with closed telemonitoring and follow-up in patients with amyotrophic lateral sclerosis is non-inferior to initiation during admission to the hospital

The primary hypothesis is that outpatient intiation of noninvasive home mechanical ventilation combined with closed telemonitoring and follow-up is non-inferior to initiation during hospitalization in patients with amyotrophic lateral sclerosis.

Inclusion Criteria:

• Age > 18 years
• Diagnosed with amyotrophic lateral sclerosis
• Indication for start of non-invasive mechanical ventilation

Exclusion Criteria:

• No informed consent
• Does not understand Danish or English
• Indication for invasive mechanical ventilation
• No morning baseline PCO2
• Hospitalization