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Abrupt changes to one's lifestyle disrupt biorhythms. Acute effects are well known from jet lag where transmeridian travel leads to insomnia, fatigue, irritability, gastrointestinal symptoms and other complaints. Several studies in the hospital environment reported dampened and misaligned biorhythms, suggesting that the inpatient experience is replete with circadian disruptors. However, comprehensive assessments of how circadian clocks are affected in intensive care and how this predicts post-operative recovery and risk are largely missing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Elective cardiac surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observation | Other | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sleep depth | Variance in sleep depth assessed as percent REM sleep of total sleep time (TST) | Up to 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Odds Ratio Product-based sleep depth | Variance in sleep depth assessed as Odds Ratio Product (ORP) which ranges between ORP=0 (deeply asleep) and ORB=2.5 (fully awake). | Up to 48 hours |
| Cognitive function assessed by the Montreal Cognitive Assessment (MoCA) |
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Inclusion Criteria:
Exclusion Criteria:
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Potential patients will be screened from outpatient clinic schedules from cardiac surgery appointments within the Perelman Center for Advanced Medicine. Patients for whom cardiac surgery is advised and who meet eligibility criteria will be approached and enrolled after their consultation with the surgeon.
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| Name | Affiliation | Role |
|---|---|---|
| Carsten Skarke, MD | University of Pennsylvania | Principal Investigator |
| Garret A FitzGerald, MD | University of Pennsylvania | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania School of Medicine | Philadelphia | Pennsylvania | 19104 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42014445 | Derived | Skarke C, El Jamal N, Genuardi MV, Brooks TG, Mrcela A, Lahens NF, Cordoza M, Sarles S, Mbadugha A, Karunamuni DR, Gupta S, Bae CJ, Sehgal A, Cappola TP, Gutsche JT, Atluri P, Desai ND, Acker MA, Grant GR, Schwab RJ, Rosen IM, FitzGerald GA. Quantifying sleep wake rhythms in the hospital environment with digital technologies. NPJ Digit Med. 2026 Apr 21;9(1):479. doi: 10.1038/s41746-026-02639-w. |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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Variance in cognitive function |
| Up to 24 hours |
| Number of recorded patient visits | Any patient visits by physicians, nurses, maintenance and cleaning staff, family members and friends are documented | 24 hours |
| Purpose of recorded patient visits | The rationale is documented descriptively for each patient visits by physicians, nurses, maintenance and cleaning staff, family members and friends | 24 hours |