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Radiotherapy is one of the main treatments for head and neck Carcinoma. The incidence of radiotherapy-related adverse events is greater than 90%, and severe adverse events may lead to the interruption of radiotherapy.
The management of nutritional, psychological, and rehabilitative issues in patients undergoing radiotherapy for head and neck cancer presents unique clinical challenges. We aimed to evaluate the efficacy of the SHINE-MDT (Supportive Holistic Interventions by Nurses and Experts via Multidisciplinary Team) in reducing radiotherapy interruptions and improving patients' quality of life (QoL) compared with usual care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| standard care group | No Intervention | The standard care group is the routine care group, that is, under the current standard antitumor treatment and follow-up mode, the patients independently decided whether to carry out nutritional and psychological intervention after the advice from the medical care department of oncology | |
| MDT care group | Experimental | The MDT care group is the whole-course multidisciplinary care intervention group, which is conducted by a multidisciplinary team composed of the oncology department, nutrition department, mental health center and rehabilitation department. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole-Course Multidisciplinary Care Intervention | Behavioral | On the basis of standard treatment, all patients were evaluated by senior practice nurses in the Department of Oncology in person at the time of enrollment (before radiotherapy) and once every week during radiotherapy, and once in person/over the phone at 1, 2, 3, and 6 months after radiotherapy. |
| Measure | Description | Time Frame |
|---|---|---|
| Radiotherapy interruption rate | Interruption of radiotherapy was defined as the actual end date of radiotherapy minus the expected end date at least 5 days | 5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life score (EORTC QLQ C30) | Quality of life score was calculated according to the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 (EORTC QLQ C30) | Weekly during radiotherapy and the first month post-treatment, and at 2, 3, and 6 months post-treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Xingchen Peng, Ph.D | West China Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West China Hospital, Sichuan University | Chengdu | Sichuan | 610041 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41396606 | Derived | Pei Y, Wang J, Li J, Chen Y, He J, Wei Z, Liu Z, Su Y, Dai T, Yin L, Deng Y, Zhou J, Tian H, Li Y, Chen X, Zhang S, Chen Y, Yan Q, Li R, Jiang Z, Hu X, Peng X. Multidisciplinary Team Support for Patients With Head and Neck Cancer Receiving Radiotherapy: A Randomized Clinical Trial. JAMA Netw Open. 2025 Dec 1;8(12):e2547590. doi: 10.1001/jamanetworkopen.2025.47590. |
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|
| Quality of life score QLQ-HN35 |
Quality of life score was calculated according to the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire QLQ-HN35 |
| Weekly during radiotherapy and the first month post-treatment, and at 2, 3, and 6 months post-treatment |
| Nutritional status (NRS 2002, PG-SGA) | Nutritional status was calculated according to Nutrition Risk Screening 2002 and Patient-Generated Subjective Global Assessment。 | Weekly during radiotherapy and the first month post-treatment, and at 2, 3, and 6 months post-treatment |
| Psychological status (DT, PHQ-9, HADS) | Psychological status was calculated according to Distress Thermometer (DT), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9) | Weekly during radiotherapy and the first month post-treatment, and at 2, 3, and 6 months post-treatment |