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3.1565 nm non-ablative fractional laser has the effects of inhibiting sebaceous gland secretion of oil, regulating collagen metabolism, and delaying changes in scalp collagen after hair loss. Previous studies have confirmed that 1565 nm non-ablative fractional laser therapy for alopecia areata has a good effect. Its possible mechanisms include increasing local blood flow, stimulating growth factors and cytokines during hair growth. At the same time, in order to achieve low energy, safe, and effective treatment without the need for hair cutting, the investigators had for the first time improved the 1565 nm non non-ablative fractional laser treatment tool, removing the original sapphire crystal cooling contact. This improvement can make the treatment head fully fit the scalp, and the excitation beam acts vertically on the treatment area, reducing energy attenuation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1565nm Non-ablative Fractional Laser | Experimental | 1565nm Non-ablative Fractional Laser |
|
| Minoxidil | Active Comparator | Minoxidil for external use |
|
| 1565nm Non-ablative Fractional Laser combined with Minoxidil for external use | Active Comparator | 1565nm Non-ablative Fractional Laser combined with Minoxidil for external use |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1565nm Non-ablative Fractional Laser | Device | 1565nm Non-ablative Fractional Laser is used for treatment once every 2 weeks, a total of 10 times. 1565nm Non-ablative Fractional Laser uses square and rectangular light spots, and the size is adjusted according to the treatment area, which is about 8-16mm, 250-300spot, 10J/cm2. |
| Measure | Description | Time Frame |
|---|---|---|
| hair mirror | Using a hair mirror, measure the hair density per unit area of the same part and field of view (the center of the longitudinal axis of the scalp and body), and calculate the number and density of hair per unit area. | 2 weeks |
| BMI | weight and height will be combined to report BMI in kg/m^2 | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lin Gao, PhD | Contact | +8602984775401 | 029 | gaolin@fmmu.edu.cn |
| Chen Yu, PhD | Contact | _8613571991903 | 029 | ycyc-2005@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dermatology Derpartment of Xijing Hospital | Recruiting | Xi'an | Shaanxi | 710032 | China |
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|
| 5% minoxidil external use | Drug | The method of use of 5% minoxidil tincture is for topical use on the scalp, 1 ml per time, 2 times per day. |
|
| 1565nm Non-ablative Fractional Laser combined with 5% minoxidil | Device | The two treatment mentioned above |
|
| ID | Term |
|---|---|
| D000505 | Alopecia |
| ID | Term |
|---|---|
| D007039 | Hypotrichosis |
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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