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| ID | Type | Description | Link |
|---|---|---|---|
| K01HL166436 | U.S. NIH Grant/Contract | View source |
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NIH funding was terminated due to new agency priorities.
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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Underdiagnosis and undertreatment is a major problem in childhood asthma management, especially in preschool-aged children. Current prognostic approaches using risk-score based tools have poor-to-modest accuracy, are impractical, and have limited evidence of efficacy in clinical settings and hence are not widely used in practice.
The objective of the study is to determine the usability, acceptability, feasibility, and preliminary efficacy of the childhood asthma passive digital marker (PDM) among pediatricians. The study will include practicing pediatricians within the IU Health Network.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Clinicians - post test only | No Intervention | N=25 control pediatric clinicians, who will receive the post test only. Each clinician will be presented with 10 randomly selected vignettes of 10 children [5 with and 5 without asthma] and asked to provide a prediction of a child's asthma risk at 6-10 years. | |
| PDM Intervention Clinicians - post test only | Experimental | N=25 intervention pediatric clinicians, who will receive the post test only. Using the PDM, each clinician will be presented with 10 randomly selected vignettes of 10 children [5 with and 5 without asthma] and asked to provide a prediction of a child's asthma risk at 6-10 years. |
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| Control Clinicians - pre and post test | No Intervention | N=25 control pediatric clinicians, who will receive the pre and post test. Each clinician will be presented with 10 randomly selected vignettes of 10 children [5 with and 5 without asthma] and asked to provide a prediction of a child's asthma risk at 6-10 years. | |
| PDM Intervention Clinicians - pre and post test | Active Comparator | N=25 intervention pediatric clinicians, who will receive the pre and post test. Using the PDM, each clinician will be presented with 10 randomly selected vignettes of 10 children [5 with and 5 without asthma] and asked to provide a prediction of a child's asthma risk at 6-10 years. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Childhood Asthma Passive Digital Marker | Other | A childhood asthma Passive Digital Marker (PDM) is an ML algorithm that is able to retrieve and synthesize pre-existing "passively" collected mother/child dyad prognostic data in "digital" electronic health record (EHR) to provide an objective and quantifiable "marker" of a child's risk (probability) and associated pathophysiological phenotype to inform clinician decision-making at point-of-care. |
| Measure | Description | Time Frame |
|---|---|---|
| Perceived PDM acceptance | Perceived PDM acceptance will be measured using a Behavioral Intention scale (BIS). | 8 to 12 months |
| Perceived PDM usability | Perceived Usability will be measured using a modified Simplified System Usability Scale (SUS). | 8 to 12 months |
| Study feasibility | Percent of successful study enrollment of eligible clinicians (>80%) | 8 to 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Prognostic accuracy | % correct clinician predictions at pre and post test | 3 to 12 months |
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Inclusion Criteria:
• Practicing pediatricians within the IU Health Network
Exclusion Criteria:
• Non-practicing pediatricians within the IU Health Network
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Indiana University | Indianapolis | Indiana | 46202 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42315888 | Derived | Owora AH, Jiang B, Shah Y. Effect of an electronic health record-integrated machine learning asthma risk marker on pediatrician prognostic accuracy during preschool age: a pilot randomized clinical trial. Sci Rep. 2026 Jun 18. doi: 10.1038/s41598-026-57759-w. Online ahead of print. |
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| Type | Date | Date Unknown |
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| Release | May 27, 2026 | |
| Reset | Jun 22, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 27, 2026 | Jun 22, 2026 | |||
| Jun 23, 2026 |
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