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The purpose of this study is to assess the impact of sarcopenic obesity (SO) on weight loss outcomes and improvement of quality of life after laparoscopic sleeve gastrectomy.
Sarcopenic obesity is a state in which a lack of muscle mass and strength coexists with an increase in fat mass, and it may affect the health outcome of people with obesity after laparoscopic sleeve gastrectomy (LSG).No studies have reported differences in weight loss outcomes between patients with SO and those with non-sarcopenic obesity (NSO) after LSG. Therefore, this study aimed to systematically evaluate the differences in weight loss and quality of life (QOL) evaluation between patients with SO and NSO after LSG and provide high-level evidence-based medical evidence for the impact of SO on weight loss in the obese population and refinement of follow-up strategies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sarcopenic obesity group | Patients who underwent LSG with FM/FFM>0.80 calculated from the cross-sectional CT image of L3 vertebra. |
| |
| Non-sarcopenic obesity group | Patients who underwent LSG with FM/FFM<0.80 calculated from the cross-sectional CT image of L3 vertebra. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic sleeve gastrectomy | Procedure | Laparoscopic sleeve gastrectomy was performed in all patients with or without SO. |
|
| Measure | Description | Time Frame |
|---|---|---|
| %EWL | Percentage excess weight loss is calculated as (initial weight - 6-month weight)/(initial weight - ideal weight) × 100%. | 6 month after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| %EWL | Percentage excess weight loss is calculated as (initial weight - 1-month weight)/(initial weight - ideal weight) × 100%. | 1 month after surgery |
| %EWL | Percentage excess weight loss is calculated as (initial weight - 3-month weight)/(initial weight - ideal weight) × 100%. |
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Inclusion Criteria:
Exclusion Criteria:
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This retrospective monocentric study included 260 obese patients who underwent LSG between January 2015 and July 2022 at the Department of Gastric Surgery, Fujian Medical University Union Hospital. All patients underwent a thorough multidisciplinary evaluation (an endocrinologist, dietician, and bariatric surgeon), and a psychiatric evaluation was obtained if considered necessary. All patients completed routine preoperative investigations, including upper gastrointestinal endoscopy, chest radiography, abdominal computed tomography (CT), abdominal ultrasound examination, and nutritional assessment. Preoperative QOL was measured using the Moorhead-Ardelt questionnaire at the same visit.
All patients in this study were operated on by the same surgical team of surgeons with more than 60 LSG experiences.Postoperative treatment was performed based on the patient's condition.
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| Name | Affiliation | Role |
|---|---|---|
| Chang-Ming Huang, Ph.D | Fujian Medical University Union Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang-ming Huang | Fuzhou | Fujian | 350001 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| ID | Term |
|---|---|
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| 3 month after surgery |
| %EWL | Percentage excess weight loss is calculated as (initial weight - 9-month weight)/(initial weight - ideal weight) × 100%. | 9 month after surgery |
| %EWL | Percentage excess weight loss is calculated as (initial weight - 12-month weight)/(initial weight - ideal weight) × 100%. | 12 month after surgery |
| %TWL | Percentage total weight loss is calculated as (initial weight - 6-month weight)/(initial weight) × 100% | 6 month after surgery |
| %TWL | Percentage total weight loss is calculated as (initial weight - 12-month weight)/(initial weight) × 100% | 12 month after surgery |
| EBMI | Excess BMI is calculated as(follow-up BMI - ideal BMI) | 6 month after surgery |
| %WL | Percentage weight loss is calculated as (follow-up weight/initial weight) × 100% | 6 month after surgery |
| MA II score | Moorhead-Ardelt QOL questionnaire is a six-item self-report questionnaire that assesses the patient's subjective impression of QOL,The total score ranges from -3 to +3 and defines five outcome groups: very poor, poor, fair, good, and very good. Good and very good outcomes were considered satisfactory. | 6 month after surgery |
| BAROS score | The Bariatric Analysis and Reporting Outcome System(BAROS)combines the Moorhead-Ardelt QOL questionnaire with other data relevant to bariatric surgery, including the %EWL, improvement in comorbid conditions, and complications.A BAROS score ≤1 was considered a failure; >1-3, fair; >3-5, good; >5-7, very good; and >7, excellent. | 6 month after surgery |
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