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In this study, the investigators will detect the expression of four potential HBV-related HCC biomarkers: PGIR,FAM3C,LAMB1 and SDC4 in tumor tissues and peripheral blood, to explore the specific molecular markers for the early diagnosis of HBV-related HCC.
Paired hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and adjacent liver tissues were selected, and the mRNA and protein expressions of the PGIR,FAM3C,LAMB1 and SDC4 biomarkers in tissues were detected by RT-PCR, western Blot and immunohistochemical analysis. At the same time, healthy subjects were selected as the control group, and mRNA and protein expression levels of the above molecules in blood were detected by RT-PCR and ELISA. At the same time, the correlation between the above biomarkers and the clinical data of patients, such as diagnosis, pathological grading, recurrence, metastasis and survival time was statistically analyzed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HBV-associated HCC group | The patient was finally diagnosed with HBV-related HCC by examination and imaging examination, and the clinicopathologic data were complete. |
| |
| negative control group | HBV positive but not HCC |
| |
| Healthy control group | Healthy crowd |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tumor tissue and blood tests | Diagnostic Test | In this study, we need to collect an extra tube of blood for routine testing and the tissue after completion of pathological examination. |
| Measure | Description | Time Frame |
|---|---|---|
| Detection of RNA and protein for diagnosis | Detect the content of the RNA and protein in tumor and serum | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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the patients admitted to the First Affiliated Hospital of Shandong First Medical University
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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Paired tumor, adjacent non-tumor liver tissues and blood samples from a cohort of HBV-related HCC patients, and blood samples from healthy subjects were selected as control group.